Department of Pediatric Endocrinology, Regency Center for Diabetes Endocrinology and Research, Kanpur; and GROW Society, Growth and Obesity Workforce; Uttar Pradesh, India.
Department of Pediatric Endocrinology, Regency Center for Diabetes Endocrinology and Research, Kanpur, Uttar Pradesh, India.
Indian Pediatr. 2020 Aug 15;57(8):750-752.
To estimate the time trend and prevalence of celiac disease in 208 children with type 1 diabetes by retrospective case review. Tissue transglutaminase (TTG IgA) levels were done within the first six months of diagnosis and annually on follow-up. Celiac disease was diagnosed in 35 (16.8%; 3 before diagnosis, 18 at initial screening and 14 on follow-up). 14 subjects with negative TTG serology at presentation, developed celiac disease after 3.9 (2.9) years (range 1.4 - 12.6 years, 85.7% within 5 years). Celiac disease is common in Indian children and adolescents with type I diabetes, developing in most within five years of diagnosis.
通过回顾性病例分析，估计了 208 例 1 型糖尿病患儿中乳糜泻的时间趋势和流行率。在诊断后的前 6 个月内和随访期间每年进行组织转谷氨酰胺酶 (TTG IgA) 水平检测。诊断出 35 例（16.8%；3 例在诊断前，18 例在初次筛查时，14 例在随访时）。14 例在初次就诊时 TTG 血清学阴性的患者，在 3.9（2.9）年后发展为乳糜泻（范围 1.4-12.6 年，85.7%在 5 年内）。乳糜泻在印度儿童和青少年 1 型糖尿病患者中较为常见，大多数在诊断后 5 年内发病。
