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阿伏苯宗在多种钌(II)支架中的掺入产生了有效的潜在抗肿瘤剂。

Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents.

机构信息

Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506, USA.

出版信息

Dalton Trans. 2020 Sep 15;49(35):12161-12167. doi: 10.1039/d0dt02016h.

DOI:10.1039/d0dt02016h
PMID:32845256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8607750/
Abstract

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

摘要

四种结构不同的含阿伏苯宗的多吡啶钌配合物在癌细胞中表现出低微摩尔和亚微摩尔的效力,比母体配体活性高 273 倍。可见光照射增强了一些配合物的细胞毒性,使它们成为联合化疗-光动力治疗的有前途的候选物。

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2
Synthesis, photophysical properties and in vitro evaluation of a chlorambucil conjugated ruthenium(ii) complex for combined chemo-photodynamic therapy against HeLa cells.一种用于联合化学-光动力疗法对抗人宫颈癌HeLa细胞的苯丁酸氮芥共轭钌(II)配合物的合成、光物理性质及体外评价
J Mater Chem B. 2017 Jun 28;5(24):4623-4632. doi: 10.1039/c7tb00702g. Epub 2017 May 22.
3
Photoinduced ligand dissociation follows reverse energy gap law: nitrile photodissociation from low energy MLCT excited states.光致配体解离遵循反向能隙定律:腈从低能量MLCT激发态的光解离。
Chem Commun (Camb). 2020 Apr 14;56(29):4070-4073. doi: 10.1039/c9cc10095d. Epub 2020 Mar 11.
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A Maltol-Containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent.含麦芽酚的钌多吡啶配合物作为一种潜在的抗癌剂。
Chemistry. 2020 Apr 16;26(22):4997-5009. doi: 10.1002/chem.201904877. Epub 2020 Mar 26.
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