Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506, USA.
Dalton Trans. 2020 Sep 15;49(35):12161-12167. doi: 10.1039/d0dt02016h.
Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.
四种结构不同的含阿伏苯宗的多吡啶钌配合物在癌细胞中表现出低微摩尔和亚微摩尔的效力,比母体配体活性高 273 倍。可见光照射增强了一些配合物的细胞毒性,使它们成为联合化疗-光动力治疗的有前途的候选物。