Ru(ii) 金属卟啉配合物在光照下于活细胞中的作用机制。
Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation.
机构信息
Chimie ParisTech, PSL University, Laboratory for Inorganic Chemical Biology, Paris, France.
出版信息
Chem Commun (Camb). 2018 Nov 20;54(93):13040-13059. doi: 10.1039/c8cc05928d.
PMID:30398487
Abstract
The unique photophysical properties of Ru(ii) polypyridyl complexes make them very attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date, there are not many studies exploring in detail the mechanism(s) of action of such compounds in living systems upon light irradiation. This feature article provides an overview of the most in-depth biological studies on such compounds.
摘要
钌（II）金属多吡啶配合物独特的光物理性质使它们成为光动力疗法（PDT）中非常有吸引力的光敏剂候选物。然而，迄今为止，很少有研究详细探讨此类化合物在光照下在活体内的作用机制。本文综述了此类化合物最深入的生物学研究。
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