黏附素-1 在肿瘤微环境中的作用。

Syndecan-1 in the Tumor Microenvironment.

机构信息

Service d'Anatomie pathologique; APHP GHU Avicenne, University Sorbonne Paris Nord, Bobigny, France.

出版信息

Adv Exp Med Biol. 2020;1272:39-53. doi: 10.1007/978-3-030-48457-6_3.

Abstract

Syndecan-1 along with the other three syndecan proteins is present in the varied components of the tumor microenvironment: fibroblasts, inflammatory tumor immunity-associated cells, vessels, and extracellular matrix. Epithelial and non-epithelial tumors may show stromal syndecans. The main relevance of stromal syndecans as tumor biomarker resides in the relationships to tumor features such as type and differentiation as well as to prognosis.

摘要

硫酸乙酰肝素蛋白聚糖-1 与其他三种硫酸乙酰肝素蛋白聚糖一起存在于肿瘤微环境的各种成分中：成纤维细胞、炎症性肿瘤免疫相关细胞、血管和细胞外基质。上皮性和非上皮性肿瘤可能显示基质硫酸乙酰肝素蛋白聚糖。基质硫酸乙酰肝素蛋白聚糖作为肿瘤标志物的主要相关性在于与肿瘤特征的关系，如类型和分化以及预后。