膀胱肿瘤经尿道单极与双极电切术：现有研究的最新系统评价与荟萃分析
Monopolar versus bipolar transurethral resection of bladder tumors: An updated systematic review and meta-analysis of existing studies.
作者信息
Xu Jianeng, Zheng Junbiao, Ma Yucheng
机构信息
Urology Surgery Department, Jiashan First People's Hospital, Jiashan City, Zhejiang Province.
Urology Surgery Department, West China Hospital, Nanchong, Sichuan, China.
出版信息
Medicine (Baltimore). 2020 Aug 21;99(34):e21768. doi: 10.1097/MD.0000000000021768.
BACKGROUND
To compare the efficacy and safety of bipolar and monopolar transurethral resection of bladder tumors (TURBT) in non-muscle invasive bladder cancer (NMIBC) treatment.
METHODS
This protocol established in this study has been reported following the preferred reporting items for systematic review and meta-analysis protocols. Web of Science, PubMed, EMBASE, and the Cochrane Library were searched for all randomized controlled trials comparing bipolar TURBT and monopolar TURBT in NMIBC treatment until 31st of June 2020. We will use a combination of Medical Subject Heading and free-text terms with various synonyms to search based on the eligibility criteria. Two investigators independently reviewed the included studies and extracted relevant data. The odds ratio and 95% confidence intervals of were used as effect estimate. I-square (I) test, substantial heterogeneity, sensitivity analysis, and publication bias assessment will be performed accordingly. Stata 15.0 and Review Manger 5.3 are used for meta-analysis and systematic review.
RESULTS
The results will be published in a peer-reviewed journal.
CONCLUSION
The results of this review will be widely disseminated through peer-reviewed publications and conference presentations. This evidence may also provide helpful evidence of the efficacy and safety of bipolar and monopolar transurethral resection of TURBT in NMIBC treatment.
PROSPERO REGISTRATION NUMBER
CRD42020151997.
背景
比较双极和单极经尿道膀胱肿瘤切除术（TURBT）在非肌层浸润性膀胱癌（NMIBC）治疗中的疗效和安全性。
方法
本研究中制定的方案已按照系统评价和Meta分析方案的首选报告项目进行了报告。检索了Web of Science、PubMed、EMBASE和Cochrane图书馆，以查找所有比较双极TURBT和单极TURBT在NMIBC治疗中的随机对照试验，检索截至2020年6月31日。我们将结合医学主题词和带有各种同义词的自由文本术语，根据纳入标准进行检索。两名研究人员独立审查纳入的研究并提取相关数据。比值比和95%置信区间用作效应估计值。将相应地进行I²（I）检验、实质性异质性检验、敏感性分析和发表偏倚评估。使用Stata 15.0和Review Manger 5.3进行Meta分析和系统评价。
结果
结果将发表在同行评审期刊上。
结论
本综述的结果将通过同行评审出版物和会议报告广泛传播。这一证据也可能为双极和单极经尿道膀胱肿瘤切除术在NMIBC治疗中的疗效和安全性提供有用的证据。
PROSPERO注册号：CRD42020151997。
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