Braun W E, Zachary A A
Department of Immunopathology, Cleveland Clinic Foundation, Ohio.
Clin Lab Med. 1988 Jun;8(2):351-72.
The HLA system of antigens identified serologically and, in some cases, by cellular techniques has shown important associations with numerous autoimmune diseases. As DNA technology becomes more widely used, there is great expectation that restriction fragment length polymorphisms (RFLP) and oligonucleotide probing of the HLA genes will soon provide for clinical use even more definitive relationships with these diseases and possibly insights into their pathogenetic mechanisms.
通过血清学方法以及在某些情况下通过细胞技术鉴定出的HLA抗原系统，已显示出与多种自身免疫性疾病有重要关联。随着DNA技术的更广泛应用，人们寄予厚望的是，HLA基因的限制性片段长度多态性（RFLP）和寡核苷酸探测将很快为临床应用提供与这些疾病更明确的关系，并可能深入了解其发病机制。
