Zmijewski C M
Crit Rev Clin Lab Sci. 1984;20(4):285-373. doi: 10.3109/10408368409165777.
This review describes the greater portion of a large number of new studies on HLA and disease association which has appeared in the literature since 1979. The majority of these are concerned with the association of certain diseases with class II major histocompatibility complex antigens. The possible biologic significance of these associations in terms of their probable etiology appears to be the prevailing theme. Current thinking regarding certain heritable diseases is described. It seems that although much has been done to resolve the genetics of insulin-dependent diabetes mellitus, other diseases such a multiple sclerosis still remain a mystery. Doubtlessly, much will be gained from DNA cloning and sequencing studies proposed for the future. A great deal of new information has been obtained relative to HLA itself. New loci have been postulated in the HLA-D/DR region through the use of powerful immunochemical procedures made possibly by the advent of modern technological advances. The impact of these developments on our understanding of the function of the MHC in man and its possible relationship to disease are discussed.
这篇综述描述了自1979年以来文献中出现的大量关于HLA与疾病关联的新研究的大部分内容。其中大多数研究关注某些疾病与II类主要组织相容性复合体抗原的关联。从可能的病因学角度来看，这些关联的潜在生物学意义似乎是主要主题。文中描述了当前对某些遗传性疾病的看法。似乎尽管在解决胰岛素依赖型糖尿病的遗传学方面已经做了很多工作，但诸如多发性硬化症等其他疾病仍然是个谜。毫无疑问，未来提议进行的DNA克隆和测序研究将带来很多收获。关于HLA本身已经获得了大量新信息。通过利用现代技术进步带来的强大免疫化学方法，在HLA-D/DR区域假定了新的基因座。讨论了这些进展对我们理解人类MHC功能及其与疾病可能关系的影响。
