ω-3 脂肪酸联合高丽红参治疗亚临床注意缺陷多动障碍患儿的疗效：一项双盲、随机、安慰剂对照试验。
Efficacy of Omega-3 and Korean Red Ginseng in Children with Subthreshold ADHD: A Double-Blind, Randomized, Placebo-Controlled Trial.
机构信息
Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Bucheon-Si, Gyeonggi-Do, Republic of Korea.
出版信息
J Atten Disord. 2021 Dec;25(14):1977-1987. doi: 10.1177/1087054720951868. Epub 2020 Aug 26.
OBJECTIVE
The purpose of the present study was to investigate the efficacy of combined omega-3 and Korean red ginseng supplementation on ADHD symptoms and cognitive function in children with subthreshold ADHD.
METHOD
120 children from 6 to 12 years with subthreshold ADHD were enrolled in this 12-week, double-blind, randomized, placebocontrolled study. The primary outcome was measured by Attention-Deficit Hyperactivity Disorder Rating Scale (ADHD-RS). Children Behavior Check List (CBCL), and neuropsychological tests assessing attention, memory, and executive function were included as secondary primary outcome measures.
RESULTS
Significant effects on the scores of ADHDRS, as well as several subscales of CBCL including ADHD and attention problem subscales were revealed.
CONCLUSION
The combination of omega-3 and Korean red ginseng may have beneficial effects in children with subthreshold ADHD. Increased clinical awareness of ADHD symptoms even at a subthreshold level is needed.
目的
本研究旨在探讨ω-3 与红参联合补充对亚临床注意缺陷多动障碍（ADHD）儿童的 ADHD 症状和认知功能的疗效。
方法
本研究纳入了 120 名 6-12 岁的亚临床 ADHD 儿童，进行为期 12 周的双盲、随机、安慰剂对照研究。采用 ADHD 评定量表（ADHD-RS）评估主要结局，采用儿童行为检查表（CBCL）和神经心理学测试评估注意力、记忆和执行功能等作为次要主要结局。
结果
研究结果显示，ω-3 与红参联合补充在 ADHD-RS 评分以及 CBCL 的几个亚量表（包括 ADHD 和注意力问题亚量表）上均有显著效果。
结论
ω-3 与红参联合补充可能对亚临床 ADHD 儿童有益。需要提高对亚临床 ADHD 症状的临床认识。
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