整合的R因子R100.1对大肠杆菌dnaA突变的抑制作用：指数生长期染色体复制的起始
Suppression of an Escherichia coli dnaA mutation by the integrated R factor R100.1: origin of chromosome replication during exponential growth.
作者信息
Chandler M, Silver L, Caro L
出版信息
J Bacteriol. 1977 Aug;131(2):421-30. doi: 10.1128/jb.131.2.421-430.1977.
Abstract
We have investigated the behavior, during exponential growth, of strains of Escherichia coli carrying a dnaA(Ts) mutation that has been suppressed by the integration of the F-like R plasmid R100.1. We present evidence showing that replication in these strains proceeds largely from the normal chromosome origin at 30 degrees C, a permissive temperature for the dnaA(Ts) gene product, whereas, at 42 degrees C, replication proceeds largely from the integrated plasmid. These conclusions are based on measurements made by deoxyribonucleic acid:deoxyribonucleic acid hybridization of the relative frequencies of the prophages Mu-1 and lambdaind- and R100.1 integrated at known locations on the E. coli chromosome in these Hfr strains.
摘要
我们研究了携带dnaA（Ts）突变的大肠杆菌菌株在指数生长期间的行为，该突变已被F样R质粒R100.1的整合所抑制。我们提供的证据表明，在30℃（dnaA（Ts）基因产物的允许温度）下，这些菌株中的复制主要从正常染色体起点开始，而在42℃时，复制主要从整合的质粒开始。这些结论是基于对这些高频重组（Hfr）菌株中，在大肠杆菌染色体已知位置整合的原噬菌体Mu-1、λind-和R100.1的相对频率进行的脱氧核糖核酸：脱氧核糖核酸杂交测量得出的。
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