Sendrasoa Fandresena Arilala, Ratovonjanahary Volatantely Tobiniaina, Razanakoto Naina Harinjara, Rakotoarisaona Mendrika Fifaliana, Raharolahy Onivola, Andrianarison Malalaniaina, Ranaivo Irina Mamisoa, Mbotinirina Viviane Estelle, Sata Moril, Ramarozatovo Lala Soavina, Rapelanoro Rabenja Fahafahantsoa
Department of Dermatology, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar.
J Asthma Allergy. 2020 Aug 12;13:265-268. doi: 10.2147/JAA.S264482. eCollection 2020.
Several studies have been done to evaluate the relationship between month of birth and atopic diseases but the results are contradictory.
We aim to evaluate the correlation between the month of birth and the prevalence of AD in Malagasy children less than 3 years.
A case-control study was conducted based on patients' data of the department of Dermatology in the University Hospital Joseph Raseta Befelatanana (UH/JRB) Antananarivo. It included 438 children less than 3 years seen in this department between January 2010 and December 2019. For each atopic dermatitis (AD) patient, two age-and sex-matched controls without a history of AD were selected from the same period.
This study included 146 AD cases and 292 non-AD controls. Our case-control study found that there is a statistically significant correlation between birth month and risk of AD in Malagasy children <3 years. Compared with people born in December, people born in April had the highest risk of AD (OR: 2.11, 95% CI 0.93-4.78), followed by people born in March (OR: 1.52, 95% CI 0.79-2,88). Asthma, allergic rhinitis and allergic conjunctivitis were significantly correlated with AD in our patients.
Our case-control study found that being born in April and March (dry season) may be associated with an increased risk of AD.
已经开展了多项研究来评估出生月份与特应性疾病之间的关系，但结果相互矛盾。
我们旨在评估出生月份与马达加斯加3岁以下儿童特应性皮炎（AD）患病率之间的相关性。
基于塔那那利佛约瑟夫·拉塞塔·贝费拉塔纳纳大学医院（UH/JRB）皮肤科患者的数据进行了一项病例对照研究。研究纳入了2010年1月至2019年12月期间在该科室就诊的438名3岁以下儿童。对于每例特应性皮炎（AD）患者，从同一时期选取两名年龄和性别匹配且无AD病史的对照。
本研究纳入了146例AD病例和292例非AD对照。我们的病例对照研究发现，马达加斯加3岁以下儿童的出生月份与AD风险之间存在统计学显著相关性。与12月出生的人相比，4月出生的人患AD的风险最高（OR：2.11，95%CI 0.93 - 4.78），其次是3月出生的人（OR：1.52，95%CI 0.79 - 2.88）。在我们的患者中，哮喘、过敏性鼻炎和过敏性结膜炎与AD显著相关。
我们的病例对照研究发现，在4月和3月（旱季）出生可能与AD风险增加有关。
