Li Jingwen, Long Xi, Zhu Chunli, Wang Ruiying, Hu Shaoping, Wang Tao, Li Jinghong, Lin Zhicheng, Xiong Nian
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ther Adv Chronic Dis. 2020 Aug 11;11:2040622320949423. doi: 10.1177/2040622320949423. eCollection 2020.
Elderly populations with underlying chronic diseases are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and have higher mortality. Parkinson's disease (PD) is a neurodegenerative disease that occurs more often in elderly people. Currently, little is known about whether patients with PD are more susceptible to novel coronavirus disease 2019 (COVID-19) and whether the treatment of PD would affect the management of COVID-19 or vice versa. Here, we report a case of a PD patient with severe COVID-19 pneumonia in Wuhan, China. After diagnosis of COVID-19, this PD patient had worsening of motor symptoms, complicated with acute hypoxemic respiratory failure, urinary tract infection, and acute encephalopathy. In addition to treatment for COVID-19 and urinary tract infection, we adjusted anti-PD medicine by stepwise increasing of dose, resulting in better control of her mobility symptoms and non-motor symptoms.
患有基础慢性病的老年人群更容易感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2），且死亡率更高。帕金森病（PD）是一种在老年人中更常见的神经退行性疾病。目前，关于帕金森病患者是否更容易感染2019冠状病毒病（COVID-19），以及帕金森病的治疗是否会影响COVID-19的治疗，反之亦然，人们知之甚少。在此，我们报告一例中国武汉的帕金森病患者发生严重COVID-19肺炎的病例。诊断为COVID-19后，该帕金森病患者的运动症状恶化，并发急性低氧性呼吸衰竭、尿路感染和急性脑病。除了对COVID-19和尿路感染进行治疗外，我们通过逐步增加剂量来调整抗帕金森病药物，从而更好地控制了她的运动症状和非运动症状。
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