肺健康与疾病中的未折叠蛋白反应
Unfolded Protein Response in Lung Health and Disease.
作者信息
Barabutis Nektarios
机构信息
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, United States.
出版信息
Front Med (Lausanne). 2020 Jul 30;7:344. doi: 10.3389/fmed.2020.00344. eCollection 2020.
Abstract
The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats. If those activities fail, it will dictate cellular execution. The current work focuses on the role of UPR in pulmonary function, by immersing into the highly interrelated network that operates toward the endothelial barrier function. A highly sophisticated UPR manipulation shall reveal new therapeutic possibilities against inflammatory lung disease, such as acute lung injury and acute respiratory distress syndrome.
摘要
未折叠蛋白反应（UPR）是一个复杂的机制，旨在保护细胞免受各种细胞外和细胞内挑战。UPR激活会产生高效的反应来对抗细胞威胁。如果这些活动失败，它将决定细胞的凋亡。当前的研究工作通过深入研究与内皮屏障功能相关的高度互联网络，聚焦于UPR在肺功能中的作用。一种高度精密的UPR调控方法可能会揭示针对炎性肺病（如急性肺损伤和急性呼吸窘迫综合征）的新治疗可能性。
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