Barabutis Nektarios
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana 71201, USA.
Endocr Metab Sci. 2021 Jun 30;3. doi: 10.1016/j.endmts.2021.100092. Epub 2021 Mar 4.
Recent evidence suggest that the endothelial barrier function is enhanced by the mild activation of the unfolded protein response (UPR), which aims to suppress abnormal increases of endoplasmic reticulum stress. Heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists exert the capacity to activate this multifaceted cellular mechanism (UPR). Thus, investigations on the signalling network involved in those events, may deliver exciting opportunities in diseases related to endothelial barrier dysfunction. The diverse spectrum of those pathologies include sepsis and Acute Respiratory Distress Syndrome (ARDS).
最近的证据表明，未折叠蛋白反应（UPR）的轻度激活可增强内皮屏障功能，该反应旨在抑制内质网应激的异常增加。热休克蛋白90抑制剂和生长激素释放激素拮抗剂具有激活这种多方面细胞机制（UPR）的能力。因此，对参与这些事件的信号网络进行研究，可能会为与内皮屏障功能障碍相关的疾病带来令人兴奋的机遇。这些病理状况的范围广泛，包括败血症和急性呼吸窘迫综合征（ARDS）。
