Sugita S, Ohnishi K, Iida S, Nomura F, Okuda K
First Department of Medicine, Chiba University School of Medicine, Japan.
Liver. 1988 Feb;8(1):1-9. doi: 10.1111/j.1600-0676.1988.tb00959.x.
The etiology of idiopathic portal hypertension (IPH) is not known. To obtain clues to the pathogenesis, an attempt was made to produce a hepatic lesion similar to that in IPH by repeated injections of aggregated killed non-pathogenic E. coli directly into the portal vein. In the treated dogs, histology of the liver showed dense fibrosis in the portal tract and an aberrant vasculature around the portal area after 1 month. Portal pressure was elevated and middle-to-small-sized portal branches were decreased in number as studied by portography. These changes closely mimic those seen in human IPH. The possibility is discussed that chronic entrance of an antigen such as bacteria from the intestine to the portal venous system plays an etiologic role in IPH.
特发性门静脉高压症（IPH）的病因尚不清楚。为了获得发病机制的线索，研究人员尝试通过将聚集的灭活非致病性大肠杆菌直接反复注入门静脉来制造一种类似于IPH的肝脏病变。在接受治疗的犬中，肝脏组织学检查显示1个月后门静脉区有致密纤维化，门静脉周围血管异常。门静脉造影研究显示门静脉压力升高，中小门静脉分支数量减少。这些变化与人类IPH所见极为相似。文中讨论了诸如细菌等抗原从肠道慢性进入门静脉系统在IPH病因学中起作用的可能性。
