[特发性门静脉高压症的肝脏病理学]
[Liver pathology in idiopathic portal hypertension].
作者信息
Liu Xia, Wang Tai-ling, Xiang Can-hong, Peng Xiang-xin, Wang Yue, Chen Nian, Zhang Min
机构信息
Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China.
出版信息
Zhonghua Gan Zang Bing Za Zhi. 2007 May;15(5):374-7.
OBJECTIVE
To study the histopathological changes of livers in idiopathic portal hypertension (IPH).
METHODS
Liver specimens from 29 cases with idiopathic portal hypertension were studied. Histological preparations of the livers were stained with haematoxylin eosin and Masson's trichrome; reticular fibers in the liver tissues were demonstrated. The slides were also stained using some immunohistochemistry methods, and the pathological changes of the livers were analyzed.
RESULTS
The characteristic changes found in these IPH livers were dense portal fibrosis; obliteration, with or without phlebitis, of the branches of the portal vein; dilatation of the sinusoids; atrophy and nodular hyperplasia of liver cells.
CONCLUSIONS
Histopathological changes of the livers in IPH are dense portal fibrosis, portal vein branch obliteration and nodular hyperplasia of liver cells. These are the main features for a histopathological diagnosis of IPH.
目的
研究特发性门静脉高压症（IPH）肝脏的组织病理学变化。
方法
对29例特发性门静脉高压症患者的肝脏标本进行研究。肝脏组织学标本用苏木精伊红染色和Masson三色染色；显示肝组织中的网状纤维。切片还用一些免疫组织化学方法染色，并分析肝脏的病理变化。
结果
这些IPH肝脏中发现的特征性变化为门静脉致密纤维化；门静脉分支闭塞，伴有或不伴有静脉炎；肝血窦扩张；肝细胞萎缩和结节性增生。
结论
IPH肝脏的组织病理学变化为门静脉致密纤维化、门静脉分支闭塞和肝细胞结节性增生。这些是IPH组织病理学诊断的主要特征。
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