Fernandez-Flores Angel, Varela-Vazquez Adrian, Mayan Maria D, Fonseca Eduardo
Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.
Department of Cellular Pathology, Hospital de la Reina, Ponferrada, Spain.
J Cutan Pathol. 2021 Feb;48(2):247-254. doi: 10.1111/cup.13856. Epub 2020 Oct 16.
Connexins are transmembrane channel proteins that interconnect adjacent cells and allow the exchange of signaling molecules between cells and the extracellular milieu. They have been investigated in many tumors to obtain information about tumor nature, behavior, and prognosis.
Herein, we present a study on the immunohistochemical expression of connexin (Cx) 43 in 16 cases of atypical fibroxanthoma (AFX). For the immunohistochemical staining, a tissue array was obtained from the paraffin-embedded blocks.
The expression was membranous and cytoplasmic in all cases. Thirteen cases (81.25%) showed strong staining. In the other three cases (18.75%), the staining was medium. None of the cases showed nuclear staining. Fifteen out of 16 cases showed a diffuse pattern, and only one case showed a focal pattern.
Our results suggest that Cx43 may play an important role in the natural behavior of AFX.
连接蛋白是跨膜通道蛋白，可使相邻细胞相互连接，并允许信号分子在细胞与细胞外环境之间交换。人们已在多种肿瘤中对其进行研究，以获取有关肿瘤性质、行为和预后的信息。
在此，我们展示了一项关于16例非典型纤维黄色瘤（AFX）中连接蛋白（Cx）43免疫组化表达的研究。对于免疫组化染色，从石蜡包埋块中获取组织芯片。
所有病例的表达均为膜性和胞质性。13例（81.25%）显示强染色。在其他3例（18.75%）中，染色为中等强度。所有病例均未显示核染色。16例中有15例显示弥漫性模式，仅1例显示局灶性模式。
我们的结果表明，Cx43可能在AFX的自然行为中起重要作用。
