影像引导下的机器人立体定向放射外科治疗颈静脉球瘤——多中心经验及文献综述
Image-guided robotic radiosurgery for glomus jugulare tumors-Multicenter experience and review of the literature.
作者信息
Ehret Felix, Kufeld Markus, Fürweger Christoph, Haidenberger Alfred, Schichor Christian, Lehrke Ralph, Fichte Susanne, Senger Carolin, Bleif Martin, Rueß Daniel, Ruge Maximilian, Tonn Jörg-Christian, Muacevic Alexander, Hempel John-Martin
机构信息
European Cyberknife Center, Munich, Germany.
Department of Stereotaxy and Functional Neurosurgery, Center for Neurosurgery, University Hospital Cologne, Cologne, Germany.
出版信息
Head Neck. 2021 Jan;43(1):35-47. doi: 10.1002/hed.26439. Epub 2020 Aug 27.
BACKGROUND
Glomus jugulare tumors (GJTs) are challenging to treat due to their vascularization and location. This analysis evaluates the effectiveness and safety of image-guided robotic radiosurgery (RRS) for GJTs in a multicenter study and reviews the existing radiosurgical literature.
METHODS
We analyzed outcome data from 101 patients to evaluate local control (LC), changes in pretreatment deficits, and toxicity. Moreover, radiosurgical studies for GJTs have been reviewed.
RESULTS
After a median follow-up of 35 months, the overall LC was 99%. Eighty-eight patients were treated with a single dose, 13 received up to 5 fractions. The median tumor volume was 5.6 cc; the median treatment dose for single-session treatments is 16 Gy, and for multisession treatments is 21 Gy. Fifty-six percentage of patients experienced symptom improvement or recovered entirely.
CONCLUSIONS
RRS is an effective primary and secondary treatment option for GJTs. The available literature suggests that radiosurgery is a treatment option for most GJTs.
背景
颈静脉球瘤（GJTs）因其血管分布和位置，治疗颇具挑战性。本分析在一项多中心研究中评估影像引导下机器人放射外科手术（RRS）治疗GJTs的有效性和安全性，并回顾现有的放射外科文献。
方法
我们分析了101例患者的结局数据，以评估局部控制（LC）、治疗前功能缺损的变化及毒性反应。此外，还对GJTs的放射外科研究进行了回顾。
结果
中位随访35个月后，总体局部控制率为99%。88例患者接受单次剂量治疗，13例接受多达5次分割治疗。肿瘤中位体积为5.6立方厘米；单次治疗的中位治疗剂量为16Gy，多次治疗为21Gy。56%的患者症状改善或完全恢复。
结论
RRS是GJTs有效的一线和二线治疗选择。现有文献表明，放射外科是大多数GJTs的一种治疗选择。
Zotero 插件