Quillardet P, Hofnung M
CNRS UA 271, INSERM U163, Unité de Programmation Moléculaire et Toxicologie Génétique, Institut Pasteur, Paris, France.
Mutat Res. 1988 May-Aug;205(1-4):107-18. doi: 10.1016/0165-1218(88)90014-6.
Bacterial tests can be used for several related purposes: the screening for genotoxic agents, genetic analysis of the mode of action of genotoxins and attempts to predict their effects in mammals. We examine various aspects of the assembly of tests into batteries with emphasis on the genetic properties of target bacterial cells. We discuss the problems of carcinogenicity prediction, the identification of particular types of DNA lesions, the study of mutagenic specificity and the elucidation of metabolic steps towards the ultimate genotoxin.
筛选遗传毒性剂、对遗传毒素作用模式进行遗传分析以及尝试预测它们在哺乳动物中的效应。我们研究了将各种测试组合成测试组的各个方面，重点关注靶细菌细胞的遗传特性。我们讨论了致癌性预测问题、特定类型DNA损伤的鉴定、诱变特异性的研究以及对最终遗传毒素代谢步骤的阐明。
