Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
The University of Melbourne, Parkville, Victoria, Australia.
Integr Cancer Ther. 2020 Jan-Dec;19:1534735420952887. doi: 10.1177/1534735420952887.
To assess the feasibility, safety, and preliminary effect of a 12-week multi-modal rehabilitation program targeted at improving health-related quality of life and physical activity levels of patients with lung cancer following treatment.
Patients with stage I to IIIA non-small cell lung cancer were included 6 to 12 weeks following completion of treatment. The intervention comprised of aerobic exercise (brisk walking), resistance training and 8-style Tai Chi. The 12-week program included 2 supervised center-based sessions per week of 90 minutes duration and home-based exercise. The primary outcomes were the feasibility and safety of the intervention. Secondary outcomes (assessed pre and post program) were physical and patient-reported outcomes.
Seventy-eight patients were approached during the 6-month recruitment period and 17 (22%) consented to the study. Eight participants (47%) met the definition of adherence to the program (attending at least 70% of supervised sessions). No serious adverse events occurred. A significant reduction in anxiety and depression was observed post-program. In addition, improvements in respiratory function, sleep quality, and some health-related quality of life domains were observed post-program. There were no significant differences in functional capacity or physical activity levels.
This multi-modal exercise training program was safe, although the feasibility of the program in its current state is not supported given the low consent rate and low adherence to the intervention.
评估一项为期 12 周的多模式康复计划在改善治疗后肺癌患者的健康相关生活质量和身体活动水平方面的可行性、安全性和初步效果。
在治疗完成后 6 至 12 周时纳入 I 期至 IIIA 期非小细胞肺癌患者。干预措施包括有氧运动（快走）、阻力训练和 8 式太极拳。12 周的方案包括每周 2 次、每次 90 分钟的监督中心基础课程和家庭锻炼。主要结果是干预措施的可行性和安全性。次要结果（在方案前和后评估）为身体和患者报告的结果。
在 6 个月的招募期间，有 78 名患者被接触，其中 17 名（22%）同意参加研究。8 名参与者（47%）符合方案依从性的定义（参加至少 70%的监督课程）。没有发生严重不良事件。在计划后观察到焦虑和抑郁显著减轻。此外，在计划后还观察到呼吸功能、睡眠质量和一些健康相关生活质量领域的改善。在功能能力或身体活动水平方面没有显著差异。
尽管由于同意率低和对干预措施的低依从性，目前该多模式运动训练计划的可行性不支持，但该计划是安全的。
