Ashby J, Purchase I F
Imperial Chemical Industries PLC, Central Toxicology Laboratory, Macclesfield, Cheshire, Great Britain.
Mutat Res. 1988 May-Aug;205(1-4):51-8. doi: 10.1016/0165-1218(88)90008-0.
It is suggested that urgent attempts should be made to define and gain general agreement for the existence of two classes of animal carcinogen, those which are genotoxic and those which are not. In the absence of such a step, attempts to validate in vivo genotoxicity assays, and to derive a meaningful structure-activity database for chemical carcinogenesis, will be frustrated. These suggestions are supported by the preliminary findings of a detailed analysis of the carcinogen database accrued by the United States National Toxicology Program. The possibility that many non-genotoxic carcinogens should be regarded as tumour-promoting agents is considered.
建议应立即采取行动，明确两类动物致癌物的存在并达成普遍共识，即遗传毒性致癌物和非遗传毒性致癌物。若不采取这一步骤，验证体内遗传毒性试验以及建立有意义的化学致癌结构-活性数据库的努力都将受挫。美国国家毒理学计划积累的致癌物数据库详细分析的初步结果支持了这些建议。文中还考虑了许多非遗传毒性致癌物应被视为肿瘤促进剂的可能性。
