重新审视酸和氢键受体在烯胺形成中的作用。
Revisiting the role of acids and hydrogen bond acceptors in enamine formation.
作者信息
Lu Zhichao, Hammond Gerald B, Xu Bo
机构信息
Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
出版信息
Org Biomol Chem. 2020 Sep 21;18(35):6849-6852. doi: 10.1039/d0ob01579b. Epub 2020 Aug 27.
PMID:32852003
Abstract
A systematic investigation into the effects of acids and hydrogen bond acceptors on the reaction rates and equilibria of enamine formation is reported. Acids can accelerate the reaction but do not change the reaction equilibria. In comparison, hydrogen bond acceptors facilitate the enamine formation via their strong hydrogen bonding interaction with the water generated in the reaction.
摘要
本文报道了一项关于酸和氢键受体对烯胺形成反应速率和平衡影响的系统研究。酸可加速反应，但不改变反应平衡。相比之下，氢键受体通过与反应中生成的水形成强氢键相互作用来促进烯胺的形成。
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