Departments of Dermatology; and.
Pathology, University of California San Francisco, San Francisco, California.
Am J Dermatopathol. 2021 Apr 1;43(4):287-290. doi: 10.1097/DAD.0000000000001765.
The objective of this retrospective study was to analyze dermatomyositis skin biopsies for the presence of eosinophils and correlate this finding with other histopathologic and clinical characteristics. Cases of dermatomyositis evaluated in a single dermatologist's adult autoimmunity practice over a 2.5-year period were identified via ICD-10 diagnosis code. Dermatopathology archives were then searched for any corresponding biopsies consistent with dermatomyositis, and those identified were assessed for eosinophils, adnexal involvement, epidermal atrophy, dermal mucin, and basement membrane thickening. Histopathologic findings were correlated with key clinical features, including itch. A total of 39 biopsies from 17 patients were included. Eosinophils were noted in 44% of biopsies (n = 17) from 12 patients. Dermal mucin deposition and adnexal interface dermatitis were noted in 72% (n = 28) and 44% (n = 17) of biopsy specimens, respectively. Of 12 patients with eosinophils present in at least 1 biopsy specimen, 11 (92%) patients had a clinical history of pruritus of their skin lesions (P = 0.052). Limitations of this study include retrospective design and small number of patients.
这项回顾性研究的目的是分析皮肌炎皮肤活检中嗜酸性粒细胞的存在，并将这一发现与其他组织病理学和临床特征相关联。通过 ICD-10 诊断代码，在一名皮肤科医生的成人自身免疫性疾病实践中确定了在 2.5 年期间评估的皮肌炎病例。然后搜索皮肤科病理学档案，以寻找任何符合皮肌炎的相应活检，并评估这些活检中的嗜酸性粒细胞、附属物受累、表皮萎缩、真皮粘蛋白和基底膜增厚。组织病理学发现与关键的临床特征相关联，包括瘙痒。共纳入了 17 名患者的 39 份活检。在 12 名患者的 17 份活检中（n=17）发现了 44%的嗜酸性粒细胞。28%（n=28）和 44%（n=17）的活检标本分别出现真皮粘蛋白沉积和附属物界面皮炎。在至少 1 份活检标本中存在嗜酸性粒细胞的 12 名患者中，11 名（92%）患者有皮肤病变瘙痒的临床病史（P=0.052）。这项研究的局限性包括回顾性设计和患者数量少。
