University Bordeaux, INSERM, LAMC, U1029, F-33600 Pessac, France.
Rosalind and Morris Goodman Cancer Research Center.
Curr Opin Oncol. 2020 Nov;32(6):631-639. doi: 10.1097/CCO.0000000000000679.
This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment.
We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasion. Recent works discovered the role of new molecular players in GBM invasion, and, most importantly, better models are emerging which better recapitulate GBM invasion.
Invasive properties of glioblastoma make complete surgical resection impossible and highly invasive cells are responsible for tumor recurrence. In this review, we focus on recent updates describing how invasive cells progress in the surrounding tissue along brain structures. We also provide an overview of the current knowledge on key cells and molecular players within the microenvironment that contribute to the invasive process. VIDEO ABSTRACT.
本综述概述了近年来在理解胶质母细胞瘤细胞与其微环境中的细胞和分子伙伴相互作用的机制方面的最新进展。
我们现在对参与胶质母细胞瘤（GBM）侵袭的细胞群体有了更好的了解。最近的研究发现了新的分子在 GBM 侵袭中的作用，更重要的是，出现了更好地再现 GBM 侵袭的模型。
GBM 的侵袭特性使得完全手术切除成为不可能，而高度侵袭性的细胞是肿瘤复发的原因。在这篇综述中，我们重点介绍了最近描述侵袭性细胞如何沿着脑结构在周围组织中进展的更新。我们还概述了目前对微环境中有助于侵袭过程的关键细胞和分子的了解。
