Department of Dermatology, University of California, San Diego, California.
Department of Medicine, Siriraj Hospital, Bangkok, Thailand.
Dermatol Surg. 2021 May 1;47(5):630-633. doi: 10.1097/DSS.0000000000002689.
Surgical and nonsurgical methods are used for treating basal cell carcinoma (BCC). Few randomized controlled trials exist on the effectiveness of the pulsed dye laser (PDL) on BCC treatment.
We investigated the effectiveness of PDL treatment in a single session for the management of nodular and superficial BCCs on the trunk and extremities of adults using a randomized, double-blind, controlled technique.
We used settings of fluence 7.5 J/cm2, 3-ms pulse duration, no dynamic cooling, 10-mm spot size, 10% overlap between pulses, and 2 stacked pulses on a 595-nm wavelength laser. Histopathologic clearance on excision of tumor with 4-mm margins was the primary outcome measure.
Twenty-four patients were included in the study, with 14 in the laser treatment group and 10 patients in the sham/control group. In total, 10/14 (71.4%) of the tumors in the treatment group were successfully treated with no residual tumor on excisional specimen histology, compared with 3/10 (30.0%) of the control group (p = .045).
Our study shows that PDL may be an effective treatment for low-risk BCCs of the trunk and extremities, but the cure rate is lower than those of other treatments for BCC. Thus, PDL under the current settings cannot be recommended.
基底细胞癌（BCC）的治疗方法包括手术和非手术方法。关于脉冲染料激光（PDL）治疗 BCC 的有效性，仅有少数随机对照试验。
我们采用随机、双盲、对照的方法，研究单次 PDL 治疗成人躯干和四肢结节性和浅表性 BCC 的疗效。
我们使用 595nm 波长激光，设置能量 7.5J/cm2、脉冲持续时间 3ms、无动态冷却、光斑大小 10mm、脉冲重叠 10%、2 个叠加脉冲。以切除肿瘤时 4mm 切缘的组织病理学完全清除为主要结局指标。
本研究共纳入 24 例患者，激光治疗组 14 例，假/对照组 10 例。治疗组的 10/14（71.4%）个肿瘤完全清除，无肿瘤残留，而对照组为 3/10（30.0%）（p =.045）。
我们的研究表明，PDL 可能是治疗躯干和四肢低风险 BCC 的有效方法，但治愈率低于其他 BCC 治疗方法。因此，目前的 PDL 治疗参数不能推荐使用。
