Klyuchareva Svetlana V, Ponomarev Igor V, Topchiy Sergey B, Pushkareva Alexandra E, Andrusenko Yury N
Department of Dermatovenereology, I.I. Mechnikov North-Western State Medical University, 47, Piskarevkiy Prospect, St. Petersburg, 195067, Russian Federation.
P.N. Lebedev Physical Institute of the Russian Academy of Sciences, 53, Leninskiy Prospect, Moscow, 119991, Russian Federation.
J Lasers Med Sci. 2019 Fall;10(4):350-354. doi: 10.15171/jlms.2019.57. Epub 2019 Oct 1.
Basal cell carcinoma (BCC) is the most prevalent form of non-melanoma skin cancer commonly arising in elderly patients. Currently, many laser systems are applied for the treatment of BCC. However, up to the present, there have been several reports concerning ocular side effects due to the laser procedure in the borders of the periorbital area. This determines the feasibility of testing new laser surgical modes for the management of periorbital BCC. This stuay aimed to estimate both the efficacy, the early post-radiated side effects and long-term outcomes of the CVL treatment of periorbital BCC. Two men and 6 women aged 50 to 77 years were diagnosed with periorbital BCC according to the data of both the clinical evaluation and histological examination of the tissue samples taken from the involved area. Six months after the laser treatment, the histological examination of skin samples from the borderline of the irradiated area was made again. All patients were followed for 24 months after the laser treatment of BCC. The laser treatment was administered during one session of copper vapor laser (CVL) (Yakhroma-Med model). The treatment included CVL radiation with a wavelength of 511 nm and 578 nm, in the ratio of 3:2. The power level was set up to 3 W, and the exposure time was equal from 200 to 600 ms. The pulse duration accounted for 15 ns. The diameter of the light spot on the skin surface amounted to 1 mm. Dual-wavelengths CVL treatment of periorbital BCC provided a complete elimination of malignant cells and dysplastic vessels during one procedure. The duration of skin healing amounted to 2-4 weeks. There were neither ocular injuries or pronounced skin side effects nor relapses within 24 months after the laser procedure. CVL treatment of periorbital BCC provides relevant cosmetic results without ocular injuries and relapses.
基底细胞癌(BCC)是最常见的非黑素瘤皮肤癌形式,常见于老年患者。目前,许多激光系统被应用于BCC的治疗。然而,到目前为止,已有多篇关于激光手术在眶周区域边界导致眼部副作用的报道。这决定了测试用于治疗眶周BCC的新激光手术模式的可行性。本研究旨在评估铜蒸气激光(CVL)治疗眶周BCC的疗效、早期放疗后副作用和长期结果。根据从受累区域采集的组织样本的临床评估和组织学检查数据,两名男性和六名年龄在50至77岁之间的女性被诊断为眶周BCC。激光治疗六个月后,再次对照射区域边界的皮肤样本进行组织学检查。所有患者在BCC激光治疗后随访24个月。激光治疗在一次铜蒸气激光(CVL)(Yakhroma-Med型号)治疗过程中进行。治疗包括波长为511nm和578nm的CVL辐射,比例为3:2。功率水平设置为3W,曝光时间为200至600ms。脉冲持续时间为15ns。皮肤表面光斑直径为1mm。双波长CVL治疗眶周BCC在一次手术中可完全消除恶性细胞和发育异常的血管。皮肤愈合时间为2至4周。激光手术后24个月内既没有眼部损伤或明显的皮肤副作用,也没有复发。CVL治疗眶周BCC可提供相关的美容效果,且无眼部损伤和复发。