Division of Cardiology, Emory University School of Medicine, 101 Woodruff Circle, Suite 319, Atlanta, GA, 30322, USA.
Curr Hypertens Rep. 2020 Aug 27;22(9):64. doi: 10.1007/s11906-020-01070-0.
Hypertensive disorders of pregnancy affect about 5-10% of pregnancies impacting maternal, fetal, and neonatal outcomes. We review the recent studies in this field and discuss the pathophysiology, diagnosis, and management of hypertension during pregnancy, as well as the short- and long-term consequences on the cardiovascular health of women.
Although the American College of Cardiology/American Heart Association revised their guidelines for hypertension in the general population in 2017, hypertension during pregnancy continues to be defined as a systolic blood pressure (SBP) ≥ 140 mmHg and/or a diastolic blood pressure (DBP) ≥ 90 mmHg, measured on two separate occasions. The addition of stage 1 hypertension will increase the prevalence of hypertension during pregnancy, identifying more women at risk of preeclampsia; however, more research is needed before changing the BP goal because a lower target BP has a risk of poor placental perfusion. Women with chronic hypertension have a higher incidence of superimposed preeclampsia, cesarean section, preterm delivery before 37 weeks' gestation, birth weight less than 2500 g, neonatal unit admission, and perinatal death. They also have a higher risk of developing cardiovascular disease later in life. The guidelines recommend low-dose aspirin for women with moderate and high risk of preeclampsia. While treating pregnant women with hypertension, the effectiveness of the antihypertensive agent must be balanced with risks to the fetus. Hypertensive disorders of pregnancy should be appropriately and promptly recognized and treated during pregnancy. They should further be co-managed by the obstetrician and cardiologist to decrease the long-term negative impact on the cardiovascular health of women.
妊娠高血压疾病影响约 5-10%的妊娠,影响母婴和新生儿结局。我们回顾该领域的最新研究,讨论妊娠期间高血压的病理生理学、诊断和管理,以及对女性心血管健康的短期和长期影响。
尽管美国心脏病学会/美国心脏协会在 2017 年修订了其普通人群高血压指南,但妊娠期间高血压仍定义为收缩压(SBP)≥140mmHg 和/或舒张压(DBP)≥90mmHg,在两次不同的时间测量。增加 1 期高血压将增加妊娠期间高血压的患病率,识别出更多患有子痫前期风险的女性;然而,在改变血压目标之前需要更多的研究,因为较低的目标血压会增加胎盘灌注不良的风险。患有慢性高血压的女性发生子痫前期、剖宫产、37 周前早产、出生体重小于 2500 克、新生儿入住新生儿重症监护病房和围产儿死亡的发生率更高。她们以后患心血管疾病的风险也更高。指南建议中度和高度子痫前期风险的女性服用小剂量阿司匹林。在治疗妊娠高血压的女性时,必须权衡降压药物对胎儿的风险。妊娠高血压疾病应在妊娠期间得到适当和及时的识别和治疗。应由妇产科医生和心脏病专家共同管理,以减少对女性心血管健康的长期负面影响。