Department of Cardiovascular Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, Japan.
J Med Ultrason (2001). 2020 Oct;47(4):555-563. doi: 10.1007/s10396-020-01036-4. Epub 2020 Aug 27.
The number of patients aged over 90 years undergoing transthoracic echocardiography (TTE) has increased. Normal echocardiographic measurement values in healthy Japanese aged 20-79 years have been reported by Daimon et al., and in those aged 10-89 years by Okura et al. To date, no researchers have published normal values in healthy Japanese aged over 90 years. To understand the echocardiographic characteristics and establish the normal range, we evaluated patients aged over 90 years who had preserved left ventricular (LV) ejection fraction without cardiovascular disease.
Enrolled in the study were consecutive patients aged over 90 years who were examined by TTE at the Ultrasound Imaging Center at Nagasaki University Hospital, Japan, between September 2009 and May 2016. We selected patients with LV ejection fraction > 55%, and without cardiac, renal, or aortic disease.
Among a total of 956 patients, 73 patients (19 males, 54 females) were admitted. Compared with females, males had significantly higher values of aortic diameter at the sinus of Valsalva and LV diastolic diameter and systolic diameter (P < 0.01), significantly lower E wave velocities (P < 0.01) and left ventricle mass (P < 0.01), and lower values of relative wall thickness (P < 0.01). Compared with subjects in their 70s and 80s in the studies by Daimon and Okura, the E and A wave velocities were higher.
We established the normal range of TTE parameters in elderly patients who had LV ejection fraction > 55% without cardiac, renal, or aortic disease. Sex differences were present as well as a tendency towards age-related changes in LV geometry and diastolic function. Most of the patients aged over 90 years had LV hypertrophy and potential diastolic dysfunction.
接受经胸超声心动图（TTE）检查的 90 岁以上患者人数有所增加。Daimon 等人报道了 20-79 岁健康日本人的正常超声心动图测量值，Okura 等人报道了 10-89 岁健康日本人的正常超声心动图测量值。迄今为止，还没有研究人员发表过 90 岁以上健康日本人的正常数值。为了了解超声心动图特征并建立正常范围，我们评估了患有左心室（LV）射血分数保留且无心血管疾病的 90 岁以上患者。
连续纳入 2009 年 9 月至 2016 年 5 月在日本长崎大学医院超声影像中心接受 TTE 检查的 90 岁以上患者。我们选择 LV 射血分数＞55%且无心脏、肾脏或主动脉疾病的患者。
在总共 956 名患者中，有 73 名患者（19 名男性，54 名女性）入选。与女性相比，男性的升主动脉窦部内径和左心室舒张末期及收缩末期内径明显更大（P＜0.01），E 波速度明显更低（P＜0.01），左心室质量明显更低（P＜0.01），相对室壁厚度明显更低（P＜0.01）。与 Daimon 和 Okura 的研究中 70 多岁和 80 多岁的受试者相比，E 波和 A 波速度更高。
我们建立了 LV 射血分数＞55%且无心脏、肾脏或主动脉疾病的老年患者 TTE 参数的正常范围。存在性别差异，以及 LV 几何形状和舒张功能随年龄相关变化的趋势。大多数 90 岁以上患者存在 LV 肥厚和潜在的舒张功能障碍。
