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Editorial: serum HBV RNA biphasic decline in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues.社论：核苷（酸）类似物治疗 HBeAg 阳性慢性乙型肝炎患者血清 HBV RNA 双相下降。
Aliment Pharmacol Ther. 2020 Sep;52(5):881-882. doi: 10.1111/apt.15975.
2
Editorial: serum HBV RNA biphasic decline in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues-authors' reply.社论：接受核苷（酸）类似物治疗的HBeAg阳性慢性乙型肝炎患者血清HBV RNA呈双相下降——作者回复
Aliment Pharmacol Ther. 2020 Sep;52(5):883-884. doi: 10.1111/apt.15993.
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Factors associated with the biphasic kinetics of serum HBV RNA in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues.核苷（酸）类似物治疗 HBeAg 阳性慢性乙型肝炎患者血清 HBV RNA 双相动力学相关因素。
Aliment Pharmacol Ther. 2020 Aug;52(4):692-700. doi: 10.1111/apt.15890. Epub 2020 Jul 1.
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Effect on HBs antigen clearance of addition of pegylated interferon alfa-2a to nucleos(t)ide analogue therapy versus nucleos(t)ide analogue therapy alone in patients with HBe antigen-negative chronic hepatitis B and sustained undetectable plasma hepatitis B virus DNA: a randomised, controlled, open-label trial.聚乙二醇干扰素 α-2a 联合核苷（酸）类似物治疗与单独核苷（酸）类似物治疗对 HBeAg 阴性慢性乙型肝炎患者持续不可检测的血浆乙型肝炎病毒 DNA 的影响：一项随机、对照、开放标签试验。
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Serum Hepatitis B Virus DNA, RNA, and HBsAg: Which Correlated Better with Intrahepatic Covalently Closed Circular DNA before and after Nucleos(t)ide Analogue Treatment?血清乙型肝炎病毒 DNA、RNA 和 HBsAg：核苷（酸）类似物治疗前后与肝内共价闭合环状 DNA 相关性更好的是哪一个？
J Clin Microbiol. 2017 Oct;55(10):2972-2982. doi: 10.1128/JCM.00760-17. Epub 2017 Jul 26.
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Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B.核苷（酸）类似物仅能使大多数慢性乙型肝炎患者的乙型肝炎 e 抗原血清学转换暂时发生。
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Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.核苷（酸）类似物长期有效治疗后乙型肝炎病毒特异性 T 细胞功能的恢复。
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Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in e antigen-positive chronic hepatitis B patients.肝内准种异质性增加与 e 抗原阳性慢性乙型肝炎患者核苷（酸）类似物停药后持续应答相关。
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HBsAg and HBcrAg as predictors of HBeAg seroconversion in HBeAg-positive patients treated with nucleos(t)ide analogues.乙肝表面抗原（HBsAg）和乙肝核心相关抗原（HBcrAg）作为接受核苷（酸）类似物治疗的HBeAg阳性患者HBeAg血清学转换的预测指标。
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本文引用的文献

1
Factors associated with the biphasic kinetics of serum HBV RNA in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues.核苷（酸）类似物治疗 HBeAg 阳性慢性乙型肝炎患者血清 HBV RNA 双相动力学相关因素。
Aliment Pharmacol Ther. 2020 Aug;52(4):692-700. doi: 10.1111/apt.15890. Epub 2020 Jul 1.
2
Baseline and kinetics of serum hepatitis B virus RNA predict response to pegylated interferon-based therapy in patients with hepatitis B e antigen-negative chronic hepatitis B.基线和血清乙型肝炎病毒 RNA 动力学可预测乙型肝炎 e 抗原阴性慢性乙型肝炎患者对聚乙二醇干扰素治疗的反应。
J Viral Hepat. 2019 Dec;26(12):1481-1488. doi: 10.1111/jvh.13195. Epub 2019 Sep 10.
3
Serum HBV RNA quantification: useful for monitoring natural history of chronic hepatitis B infection.血清 HBV RNA 定量：有助于监测慢性乙型肝炎感染的自然史。
BMC Gastroenterol. 2019 Apr 16;19(1):53. doi: 10.1186/s12876-019-0966-4.
4
Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection.血清乙型肝炎病毒 RNA：慢性乙型肝炎病毒感染的新潜在生物标志物。
Hepatology. 2019 Apr;69(4):1816-1827. doi: 10.1002/hep.30325. Epub 2019 Mar 20.
5
Serum HBV RNA as a Predictor of Peginterferon Alfa-2a Response in Patients With HBeAg-Positive Chronic Hepatitis B.血清 HBV RNA 作为预测 HBeAg 阳性慢性乙型肝炎患者对聚乙二醇干扰素 alfa-2a 反应的指标。
J Infect Dis. 2018 Aug 24;218(7):1066-1074. doi: 10.1093/infdis/jiy270.
6
Hepatitis B Virus Serum DNA andRNA Levels in Nucleos(t)ide Analog-Treated or Untreated Patients During Chronic and Acute Infection.慢性和急性感染期间核苷（酸）类似物治疗或未治疗患者的乙型肝炎病毒血清 DNA 和 RNA 水平。
Hepatology. 2018 Dec;68(6):2106-2117. doi: 10.1002/hep.30082. Epub 2018 Sep 22.
7
Host and viral factors associated with serum hepatitis B virus RNA levels among patients in need for treatment.与需要治疗的患者血清乙型肝炎病毒 RNA 水平相关的宿主和病毒因素。
Hepatology. 2018 Sep;68(3):839-847. doi: 10.1002/hep.29872. Epub 2018 Apr 27.
8
Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound.血清乙型肝炎病毒 RNA 是包裹前基因组 RNA 的，它可能与病毒感染的持续存在和反弹有关。
J Hepatol. 2016 Oct;65(4):700-710. doi: 10.1016/j.jhep.2016.05.029. Epub 2016 May 28.
9
Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors.血清乙型肝炎病毒 RNA 水平作为治疗期间乙型肝炎表面抗原血清学转换的早期预测指标。
Hepatology. 2015 Jan;61(1):66-76. doi: 10.1002/hep.27381. Epub 2014 Nov 25.
10
On-treatment low serum HBV RNA level predicts initial virological response in chronic hepatitis B patients receiving nucleoside analogue therapy.治疗期间低血清HBV RNA水平可预测接受核苷类似物治疗的慢性乙型肝炎患者的初始病毒学应答。
Antivir Ther. 2015;20(4):369-75. doi: 10.3851/IMP2777. Epub 2014 Apr 16.

社论：核苷（酸）类似物治疗 HBeAg 阳性慢性乙型肝炎患者血清 HBV RNA 双相下降。

Editorial: serum HBV RNA biphasic decline in patients with HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues.

机构信息

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China.

出版信息

Aliment Pharmacol Ther. 2020 Sep;52(5):881-882. doi: 10.1111/apt.15975.

DOI:10.1111/apt.15975
PMID:32852825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7496356/
Abstract

This article is linked to Liu et al papers. To view these articles, visit https://doi.org/10.1111/apt.15890 and https://doi.org/10.1111/apt.15993

摘要

本文与 Liu 等人的论文相关。要查看这些文章，请访问 https://doi.org/10.1111/apt.15890 和 https://doi.org/10.1111/apt.15993。