Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Brazil.
Pronto Socorro Cardiológico de Pernambuco (PROCAPE), University of Pernambuco, Recife, Brazil.
J Clin Hypertens (Greenwich). 2020 Oct;22(10):1936-1940. doi: 10.1111/jch.14012. Epub 2020 Aug 27.
Disagreements in office brachial and central blood pressure (BP) have resulted in the identification of novel hypertension phenotypes, namely isolated central hypertension (ICH) and isolated brachial hypertension (IBH). This study investigated the relationship of ICH and IBH with ambulatory BP phenotypes among 753 individuals (mean age = 47.6 ± 15.2 years, 48% males) who underwent office and 24-hours brachial and central BP measures using a Mobil-O-Graph PWA monitor. Thresholds for elevated office central and brachial BP were 130/90 and 140/90 mm Hg. Results of multivariable analysis adjusted for potential confounders showed that ICH (n = 25) had 3.71-fold (95% CI 1.48-9.32; P = .005) greater risk of masked hypertension than normal brachial/central BP (n = 362), while IBH (n = 20) had 4.65-fold (95% CI 1.76-12.25; P = .002) greater risk of white coat hypertension compared with combined brachial/central hypertension (n = 346). These findings suggest that the diagnosis of ICH and IBH might be useful in identifying individuals at higher risk of presenting discordant office and ambulatory BP phenotypes.
办公室臂部和中心血压（BP）的差异导致了新型高血压表型的鉴定，即孤立性中心高血压（ICH）和孤立性臂部高血压（IBH）。本研究调查了在 753 名个体（平均年龄 47.6 ± 15.2 岁，48%为男性）中，ICH 和 IBH 与动态血压表型之间的关系，这些个体使用 Mobil-O-Graph PWA 监测仪接受了办公室和 24 小时臂部和中心 BP 测量。升高的办公室中心和臂部 BP 的阈值分别为 130/90 和 140/90 mmHg。经多变量分析调整潜在混杂因素后，结果显示 ICH（n = 25）发生隐匿性高血压的风险比正常臂部/中心 BP（n = 362）高 3.71 倍（95%CI 1.48-9.32；P =.005），而 IBH（n = 20）发生白大衣高血压的风险比联合臂部/中心高血压（n = 346）高 4.65 倍（95%CI 1.76-12.25；P =.002）。这些发现表明，ICH 和 IBH 的诊断可能有助于识别具有更高出现不一致的办公室和动态血压表型风险的个体。
