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比较儿童二尖瓣修复术中使用人工腱索与天然腱索的中期结果。

Mid-Term Results Comparing the Use of Artificial Chords Versus Native Chords for Mitral Valve Repair in Children.

机构信息

Department of Cardio-Thoracic Surgery, 65282National Heart Institute, Kuala Lumpur, Malaysia.

Department of Clinical Research, 65282National Heart Institute, Kuala Lumpur, Malaysia.

出版信息

World J Pediatr Congenit Heart Surg. 2020 Sep;11(5):579-586. doi: 10.1177/2150135120930678.

Abstract

BACKGROUND

Our study is aimed at evaluating the mid-term surgical outcomes of mitral valve repair in children using various chordal reconstructive procedures (autologous in situ chords or artificial chords).

METHODS

A retrospective analysis of 154 patients who underwent mitral valve repair using various chordal reconstructive procedures from 1992 to 2012. Patients were divided into group A and group B based on use of artificial chords and autologous in situ chords, respectively, for the repair. There were 102 (66.2%) patients in group A and 52 (33.8%) patients in group B. The mean age at repair was 11.1 ± 4.5 years. Associated cardiac anomalies were found in 94 (61%) patients.

RESULTS

The median follow-up period was 4.2 years (Interquartile range: 2.0-9.9). There were two (1.3%) early deaths and five (3.2%) late deaths. There was no significant difference in survival at 15 years between the two groups (group A: 91.8% vs group B: 95.1%; = .66). There was no significant difference in the freedom from reoperation at 15 years between group A (79.4%) and group B (97.2%; = .06). However, there was significant difference in freedom from valve failure between group A (56.5%) and group B (74.1%; = .03). Carpentier functional class III and postoperative residual mitral regurgitation (2+ MR, ie, mild-moderate MR) were the risk factors for valve failure.

CONCLUSIONS

Severity of the disease and its progression has profound effect on the valve repair than the technique itself. Both chordal reconstructive procedures can be used to produce satisfactory results in children.

摘要

背景

本研究旨在评估使用各种瓣环成形术(自体原位腱索或人工腱索)修复儿童二尖瓣的中期手术结果。

方法

回顾性分析 1992 年至 2012 年间采用各种瓣环成形术修复二尖瓣的 154 例患者。根据修复时使用人工腱索和自体原位腱索的不同,将患者分为 A 组和 B 组,A 组 102 例(66.2%),B 组 52 例(33.8%)。修复时的平均年龄为 11.1±4.5 岁。94 例(61%)患者合并心脏畸形。

结果

中位随访时间为 4.2 年(四分位间距:2.0-9.9)。早期死亡 2 例(1.3%),晚期死亡 5 例(3.2%)。两组 15 年生存率无显著差异(A 组:91.8%比 B 组:95.1%;=0.66)。两组 15 年免于再次手术的比例无显著差异(A 组:79.4%比 B 组:97.2%;=0.06)。然而,A 组(56.5%)与 B 组(74.1%)在瓣膜衰竭方面无显著差异(=0.03)。Carpentier 功能分级 III 级和术后残余二尖瓣反流(2+MR,即轻度至中度 MR)是瓣膜衰竭的危险因素。

结论

疾病的严重程度及其进展对瓣膜修复的影响甚于技术本身。两种瓣环成形术均可用于儿童,获得满意的效果。

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