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[智利弯曲杆菌病的微生物诊断与流行病学监测:现状与进一步挑战]

[Microbial diagnosis and epidemiological surveillance of campylobacteriosis in Chile: Present state and further challenges].

作者信息

Collado Luis

机构信息

Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.

出版信息

Rev Chilena Infectol. 2020 Jun;37(3):244-251. doi: 10.4067/s0716-10182020000300244.

Abstract

Campylobacter spp. is considered as the first etiologic agent of diarrhea in developed countries and the second or third in developing countries. The high incidence of Campylobacter gastroenteritis and its possible post-infection sequelae (reactive arthritis, Miller-Fisher syndrome or Guillain-Barré syndrome) give it great importance from the socioeconomic point of view. However, in most developing countries there is no routine microbial diagnosis of this pathogen. In Chile, campylobacteriosis is notifiable since 1983. However, the lack of routine diagnosis by clinical laboratories has made it difficult to know the true prevalence of this pathogen in both intestinal and extra-intestinal infections. In addition, although campylobacteriosis is a zoonotic disease, the diagnosis of this pathogen is not considered within the Chilean Food Sanitary Regulations. All this results in a lack of knowledge about the epidemiology of Campylobacter spp disease in Chile. Therefore, the objective of this review is to analyze the situation of campylobacteriosis in the last two decades in Chile and to determine the challenges that remain to achieve an effective microbial diagnosis and epidemiologic surveillance.

摘要

弯曲杆菌属被认为是发达国家腹泻的首要病因,在发展中国家则是第二或第三病因。弯曲杆菌性肠胃炎的高发病率及其可能的感染后后遗症(反应性关节炎、米勒-费希尔综合征或吉兰-巴雷综合征),从社会经济角度来看使其具有重要意义。然而,在大多数发展中国家,对这种病原体没有进行常规微生物诊断。在智利,自1983年起弯曲杆菌病须上报。然而,临床实验室缺乏常规诊断,使得难以了解该病原体在肠道和肠道外感染中的真实流行情况。此外,尽管弯曲杆菌病是一种人畜共患病,但智利食品卫生法规中并未考虑对这种病原体进行诊断。所有这些导致对智利弯曲杆菌属疾病的流行病学缺乏了解。因此,本综述的目的是分析智利过去二十年中弯曲杆菌病的情况,并确定在实现有效的微生物诊断和流行病学监测方面仍然存在的挑战。

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