Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Am J Reprod Immunol. 2021 Jan;85(1):e13326. doi: 10.1111/aji.13326. Epub 2020 Sep 13.
The objective of the study was to investigate whether maternal history of recurrent pregnancy loss (RPL) is associated with offspring childhood ophthalmic morbidity.
A hospital-based cohort analysis comparing long-term offspring ophthalmic morbidity in women with and without a history of RPL was performed. Ophthalmic morbidity included hospitalizations involving a pre-defined set of ICD-9 codes. Offspring with congenital anomalies, perinatal mortality cases, and multifetal pregnancies were excluded from the analysis. Cumulative morbidity incidence was compared using Kaplan-Meier survival curves, and the risk of long-term ophthalmic morbidity was assessed by Cox proportional hazards model after adjustment for confounders.
During the study period, 242,187 newborns met the inclusion criteria; 5% (12,182) of them were offspring born to mothers with a history of RPL. Ophthalmic morbidity was significantly more common in the RPL group (1.3% vs 0.9%, p < .001, Kaplan-Meier log-rank p < .001). Adjustment for confounders, such as maternal age, gestational age, hypertensive disorders, and maternal diabetes, using Cox regression found that being born to a mother with RPL was independently associated with long-term ophthalmic morbidity (adjusted HR 1.35, 95% CI 1.15-1.59, p < .001).
Being born to a mother with RPL is independently associated with an increased risk of ophthalmic morbidity.
本研究旨在探讨复发性妊娠丢失（RPL）的母体史是否与子女儿童期眼部发病相关。
采用基于医院的队列分析，比较有和无 RPL 史的女性的长期子女眼部发病情况。眼部发病包括涉及 ICD-9 编码预定义集的住院治疗。从分析中排除先天性畸形、围产期死亡病例和多胎妊娠的子女。使用 Kaplan-Meier 生存曲线比较累积发病发病率，并在调整混杂因素后，使用 Cox 比例风险模型评估长期眼部发病风险。
在研究期间，符合纳入标准的新生儿有 242187 名，其中 5%（12182 名）为 RPL 母亲所生子女。RPL 组的眼部发病明显更为常见（1.3%比 0.9%，p<0.001，Kaplan-Meier 对数秩检验 p<0.001）。使用 Cox 回归调整混杂因素，如母亲年龄、胎龄、高血压疾病和母亲糖尿病后，发现子女由 RPL 母亲所生与长期眼部发病独立相关（调整后的 HR 1.35，95%CI 1.15-1.59，p<0.001）。
子女由 RPL 母亲所生与眼部发病风险增加独立相关。
