儿童先天性 Zika 病毒综合征的言语语言障碍：系统评价。

Speech-language disorders in children with congenital Zika virus syndrome: A systematic review.

机构信息

Language and Hearing Sciences Department, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.

Language and Hearing Sciences Department of the Professor Antônio Garcia Filho Campus, Federal University of Sergipe, Lagarto, Sergipe, Brazil.

出版信息

Int J Pediatr Otorhinolaryngol. 2020 Nov;138:110309. doi: 10.1016/j.ijporl.2020.110309. Epub 2020 Aug 12.

DOI:10.1016/j.ijporl.2020.110309

PMID:32853874

Abstract

INTRODUCTION

Having verified the true association between the Zika virus and the occurrence of microcephaly, studies were conducted to evaluate the effects of the infection on fetal development. Congenital Zika virus syndrome is a currently known condition but little addressed regarding speech, language, and hearing disorders in children.

OBJECTIVE

To conduct a systematic review of speech, language, and hearing disorders in children with congenital Zika virus syndrome.

METHODS

This systematic review followed the PRISMA instructions and the Joanna Briggs Institute guidelines, and it was registered in PROSPERO (CRD42018111764). The databases consulted were Cochrane, SciELO, PubMed, LILACS, Scopus, Web of Science, and ScienceDirect. OpenGrey and OpenThesis were used to partially capture the "grey literature". Observational studies of children with microcephaly due to congenital Zika virus syndrome were included. The risk of bias was analyzed using the 2017 Joanna Briggs Institute.

RESULTS

707 records were obtained and, after excluding the duplicates, 644 studies remained. After applying the inclusion criteria, 24 articles were considered eligible. Children with congenital Zika virus syndrome presented abnormal persistence of primitive reflexes (94.7%), impaired cognitive development (95.1%), delayed neuropsychomotor development (between 92.8 and 100%), hypertonia (between 74.7% and 90.1%), impaired language development (between 68.42% and 100%), retrognathia (38.6%), craniofacial disproportion (between 32.9% and 95.8%), altered tongue frenulum (between 30% and 36.36%), the absence of stapedial reflexes (27.3%), dysphagia (between 14% and 88.9%), and hearing changes (between 5.8% and 68.42%).

CONCLUSION

Children with congenital Zika virus syndrome may have speech, language, and hearing disorders such as hearing loss, dysphagia, alteration in the tongue frenulum, and delays in neuropsychomotor and language development.

摘要

引言

在证实寨卡病毒与小头畸形的发生之间存在真实关联后，人们开展了研究以评估该感染对胎儿发育的影响。先天性寨卡病毒综合征是一种已知病症，但对于儿童的言语、语言和听力障碍却鲜少涉及。

目的

对先天性寨卡病毒综合征患儿的言语、语言和听力障碍进行系统评价。

方法

本系统评价遵循 PRISMA 指令和乔安娜·布里格斯研究所指南，并在 PROSPERO（CRD42018111764）中进行了注册。检索的数据库包括 Cochrane、SciELO、PubMed、LILACS、Scopus、Web of Science 和 ScienceDirect。OpenGrey 和 OpenThesis 用于部分捕获“灰色文献”。纳入患有先天性寨卡病毒综合征所致小头畸形的儿童的观察性研究。使用 2017 年乔安娜·布里格斯研究所评估偏倚风险。

结果

获得了 707 条记录，排除重复记录后，剩余 644 项研究。在应用纳入标准后，有 24 篇文章被认为符合条件。先天性寨卡病毒综合征患儿表现出原始反射持续存在异常（94.7%）、认知发育受损（95.1%）、神经运动发育迟缓（92.8%至 100%）、高张力（74.7%至 90.1%）、语言发育受损（68.42%至 100%）、下颌后缩（38.6%）、颅面比例失调（32.9%至 95.8%）、舌系带异常（30%至 36.36%）、镫骨反射缺失（27.3%）、吞咽困难（14%至 88.9%）和听力改变（5.8%至 68.42%）。