Norhayati Mohd Noor, Che Yusof Ruhana, Azman Yacob Mohd
Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Medical Practice Division, Ministry of Health, Federal Government Administrative Centre, Putrajaya, Malaysia.
Front Med (Lausanne). 2022 Jan 27;8:783982. doi: 10.3389/fmed.2021.783982. eCollection 2021.
Vaccination is an essential intervention to curb the coronavirus disease 2019 (COVID-19) pandemic. This review aimed to estimate the pooled proportion of COVID-19 vaccine acceptance worldwide.
A systematic search of the MEDLINE (PubMed) database using "COVID-19," "vaccine" and "acceptance" to obtain original research articles published between 2020 and July 2021. Only studies with full text and that were published in English were included. The Joanna Briggs Institute meta-analysis was used to assess the data quality. The meta-analysis was performed using generic inverse variance with a random-effects model using the Review Manager software.
A total of 172 studies across 50 countries worldwide were included. Subgroup analyses were performed with regard to vaccine acceptance, regions, population, gender, vaccine effectiveness, and survey time. The pooled proportion of COVID-19 vaccine acceptance was 61% (95% CI: 59, 64). It was higher in Southeast Asia, among healthcare workers, in males, for vaccines with 95% effectiveness, and during the first survey.
COVID-19 vaccine acceptance needs to be increased to achieve herd immunity to protect the population from the disease. It is crucial to enhance public awareness of COVID-19 vaccination and improve access to vaccines.
PROSPERO 2021, identifier CRD42021268645.
接种疫苗是遏制2019冠状病毒病（COVID-19）大流行的一项重要干预措施。本综述旨在估计全球范围内接受COVID-19疫苗接种的合并比例。
使用“COVID-19”、“疫苗”和“接受度”对MEDLINE（PubMed）数据库进行系统检索，以获取2020年至2021年7月期间发表的原创研究文章。仅纳入全文发表且为英文的研究。采用乔安娜·布里格斯研究所的荟萃分析来评估数据质量。使用Review Manager软件，采用通用逆方差和随机效应模型进行荟萃分析。
共纳入全球50个国家的172项研究。对疫苗接受度、地区、人群、性别、疫苗效力和调查时间进行了亚组分析。接受COVID-19疫苗接种的合并比例为61%（95%置信区间：59, 64）。在东南亚、医护人员、男性中，对于效力为95%的疫苗以及在首次调查期间，该比例更高。
需要提高COVID-19疫苗的接受度，以实现群体免疫，保护人群免受该疾病侵害。提高公众对COVID-19疫苗接种的认识并改善疫苗可及性至关重要。
PROSPERO 2021，标识符CRD42021268645。
