Department of Pathology, University of Alabama at Birminham, Birmingham, AL, United States.
Department of Pathology, University of Alabama at Birminham, Birmingham, AL, United States.
Pathol Res Pract. 2020 Oct;216(10):153140. doi: 10.1016/j.prp.2020.153140. Epub 2020 Aug 2.
Clear cell hidradenoma (CCH) is an uncommon adnexal tumor usually arising from eccrine glands and commonly seen on the face and the upper extremities. CCH occurring in the breast is extremely rare. Herein we report a case of MAML2-rearranged CCH of breast with a papillary architecture closely mimicking intraductal papilloma, adenomyoepithelioma and low-grade mucoepidermoid carcinoma, thus representing a source of diagnostic confusion. An overview of salient histologic features and immunophenotypes to distinguish CCH and low-grade mucoepidermoid carcinoma is also integrated into the report.
透明细胞汗腺瘤（CCH）是一种不常见的附属器肿瘤，通常来源于外分泌腺，常见于面部和上肢。发生于乳腺的 CCH 极为罕见。本文报道了一例乳腺 MAML2 重排型 CCH，其具有乳头状结构，与导管内乳头状瘤、腺肌上皮瘤和低级别黏液表皮样癌极为相似，因此存在诊断混淆。本文还概述了有助于鉴别 CCH 和低级别黏液表皮样癌的重要组织学特征和免疫表型。
