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红曲对代谢性疾病的影响:作用机制的研究进展。

Impact of Red Yeast Rice on Metabolic Diseases: A Review of Possible Mechanisms of Action.

机构信息

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, People's Republic of China.

Sichuan Fuzheng Pharmaceutical Company, Limited, Chengdu, Sichuan 610041, People's Republic of China.

出版信息

J Agric Food Chem. 2020 Sep 30;68(39):10441-10455. doi: 10.1021/acs.jafc.0c01893. Epub 2020 Sep 9.

Abstract

Metabolic diseases constitute a major public health burden and are linked with high morbidity and mortality. They comprise atherosclerosis dyslipidemia, diabetes, hypertension, and obesity. However, there is no single drug that can simultaneously treat multiple diseases with complex underlying mechanisms. Therefore, it is necessary to identify a class of adjuvant drugs that block the development of metabolic diseases from a preventive perspective. Red yeast rice is a food fermentation product widely used to promote blood circulation and remove blood stasis. Modern pharmacology has shown that red yeast rice exerts potential protective effects on the liver, pancreas, blood vessels, and intestines. Therefore, this study was carried out to analyze and summarize the effect of red yeast rice on several metabolic diseases and the mechanisms of action involved. It was found that red yeast rice may be beneficial in the prevention and treatment of metabolic diseases.

摘要

代谢性疾病是重大的公共卫生负担,与高发病率和死亡率相关。它们包括动脉粥样硬化、血脂异常、糖尿病、高血压和肥胖症。然而,没有一种药物可以同时治疗多种具有复杂潜在机制的疾病。因此,有必要从预防的角度确定一类辅助药物来阻止代谢性疾病的发展。红曲米是一种广泛用于促进血液循环和祛瘀的食品发酵产品。现代药理学表明,红曲米对肝脏、胰腺、血管和肠道具有潜在的保护作用。因此,本研究旨在分析和总结红曲米对几种代谢性疾病的作用及其作用机制。结果发现,红曲米可能有益于代谢性疾病的预防和治疗。

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