School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, People's Republic of China.
Department of Pharmacy, Qilu Children's Hospital, Shandong University, Jinan 250022, China.
Future Microbiol. 2020 Jul;15:1075-1090. doi: 10.2217/fmb-2019-0343. Epub 2020 Aug 28.
Recently, the incidence of invasive fungal infections has significantly increased. is the most common opportunistic fungal pathogen that infects humans. The limited number of available antifungal agents and the emergence of drug resistance pose difficulties to treatment, thus new antifungals are urgently needed. Through their functions in DNA replication, DNA repair and transcription, histone acetyltransferases (HATs) and histone deacetylases (HDACs) perform essential functions relating to growth, virulence, drug resistance and stress responses of . Here, we summarize the physiological and pathological functions of HATs/HDACs, potential antifungal targets and underlying antifungal compounds that impact histone acetylation and deacetylation. We anticipate this review will stimulate the identification of new HAT/HDAC-related antifungal targets and antifungal agents.
最近，侵袭性真菌感染的发病率显著增加。 是最常见的机会性真菌病原体，可感染人类。现有的抗真菌药物数量有限，且出现了耐药性，这给治疗带来了困难，因此急需新的抗真菌药物。通过在 DNA 复制、DNA 修复和转录过程中发挥作用，组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）在真菌的生长、毒力、耐药性和应激反应中发挥着至关重要的作用。在这里，我们总结了 HATs/HDACs 的生理和病理功能、潜在的抗真菌靶点以及影响组蛋白乙酰化和去乙酰化的潜在抗真菌化合物。我们期望这篇综述将刺激新的 HAT/HDAC 相关抗真菌靶点和抗真菌药物的发现。
