文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

组蛋白乙酰化修饰对真菌次生代谢产物生物合成的调控

Regulation of Histone Acetylation Modification on Biosynthesis of Secondary Metabolites in Fungi.

作者信息

Hou Xuwen, Liu Liyao, Li Yu, Wang Pengfei, Pan Xiaoqian, Xu Dan, Lai Daowan, Zhou Ligang

机构信息

Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China.

出版信息

Int J Mol Sci. 2024 Dec 24;26(1):25. doi: 10.3390/ijms26010025.

DOI:10.3390/ijms26010025
PMID:39795886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11720177/
Abstract

The histone acetylation modification is a conservative post-translational epigenetic regulation in fungi. It includes acetylation and deacetylation at the lysine residues of histone, which are catalyzed by histone acetyltransferase (HAT) and deacetylase (HDAC), respectively. The histone acetylation modification plays crucial roles in fungal growth and development, environmental stress response, secondary metabolite (SM) biosynthesis, and pathogenicity. One of the most important roles is to regulate the gene expression that is responsible for SM biosynthesis in fungi. This mini-review summarized the regulation of histone acetylation modification by HATs and HDACs on the biosynthesis of SMs in fungi. In most cases, histone acetylation by HATs positively regulated the biosynthesis of fungal SMs, while HDACs had their negative regulations. Some HATs and HDACs were revealed to regulate fungal SM biosynthesis. Hda1 was found to be the most efficient regulator to affect the biosynthesis of SMs in fungi. The regulated fungal species were mainly from the genera of , , , , , , and . With the strategy of histone acetylation modification, the biosynthesis of some harmful SMs will be inhibited, while the production of useful bioactive SMs will be promoted in fungi. The subsequent research should focus on the study of regulatory mechanisms.

摘要

组蛋白乙酰化修饰是真菌中一种保守的翻译后表观遗传调控。它包括组蛋白赖氨酸残基的乙酰化和去乙酰化，分别由组蛋白乙酰转移酶（HAT）和去乙酰化酶（HDAC）催化。组蛋白乙酰化修饰在真菌的生长发育、环境应激反应、次级代谢产物（SM）生物合成和致病性中起关键作用。其中最重要的作用之一是调节负责真菌中SM生物合成的基因表达。这篇综述总结了HATs和HDACs对真菌中SM生物合成的组蛋白乙酰化修饰调控。在大多数情况下，HATs介导的组蛋白乙酰化正向调控真菌SM的生物合成，而HDACs则具有负向调控作用。一些HATs和HDACs被揭示可调控真菌SM生物合成。发现Hda1是影响真菌中SM生物合成的最有效调节因子。受调控的真菌物种主要来自 、 、 、 、 、 和 属。通过组蛋白乙酰化修饰策略，真菌中一些有害SM的生物合成将受到抑制，而有用生物活性SM的产生将得到促进。后续研究应集中在调控机制的研究上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99b/11720177/d2aa89d231a8/ijms-26-00025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99b/11720177/d2aa89d231a8/ijms-26-00025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99b/11720177/d2aa89d231a8/ijms-26-00025-g001.jpg

相似文献

[1]
Regulation of Histone Acetylation Modification on Biosynthesis of Secondary Metabolites in Fungi.

Int J Mol Sci. 2024-12-24

[2]
Exploring the multifaceted roles of histone deacetylase inhibitor vorinostat in the cell growth, mycelial morphology, pigments, and citrinin biosynthesis of Monascus purpureus.

Arch Microbiol. 2025-3-19

[3]
Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum.

Lett Appl Microbiol. 2017-11

[4]
The Histone Deacetylases HosA and HdaA Affect the Phenotype and Transcriptomic and Metabolic Profiles of .

Toxins (Basel). 2019-9-7

[5]
Advances in understanding the roles of plant HAT and HDAC in non-histone protein acetylation and deacetylation.

Planta. 2024-9-12

[6]
Inhibition of histone acetylation and deacetylation enzymes affects longevity, development, and fecundity in the pea aphid (Acyrthosiphon pisum).

Arch Insect Biochem Physiol. 2019-9-9

[7]
Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression.

Trends Plant Sci. 2015-10

[8]
Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.

Proc Natl Acad Sci U S A. 2011-8-8

[9]
Roles of Histone Acetyltransferases and Deacetylases in the Retinal Development and Diseases.

Mol Neurobiol. 2023-4

[10]
The Fng3 ING protein regulates H3 acetylation and H4 deacetylation by interacting with two distinct histone-modifying complexes.

New Phytol. 2022-9

引用本文的文献

[1]
Unlocking the therapeutic potential of the STING signaling pathway in anti-tumor treatment.

Clin Exp Med. 2025-8-12

[2]
Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial.

Am J Transplant. 2025-9

[3]
Marine-Derived Bioactive Compounds: A Promising Strategy for Ameliorating Skeletal Muscle Dysfunction in COPD.

Mar Drugs. 2025-4-4

[4]
PA System in the Pathogenesis of Ischemic Stroke.

Arterioscler Thromb Vasc Biol. 2025-5

[5]
β-Caryophyllene and Statins in Bone Fracture Healing - A Narrative Review.

Orthop Res Rev. 2025-1-23

[6]
Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression.

Adv Sci (Weinh). 2025-4

[7]
Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity.

Adv Sci (Weinh). 2025-4

[8]
X-Chromosome-Linked miRNAs Regulate Sex Differences in Cardiac Physiology.

Circ Res. 2025-1-31

[9]
Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4.

Transl Oncol. 2025-2

[10]
The Roles of T cells in Immune Checkpoint Inhibitor-Induced Arthritis.

Aging Dis. 2024-7-26

本文引用的文献

[1]
Epigenetic Regulation of Fungal Secondary Metabolism.

J Fungi (Basel). 2024-9-13

[2]
Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungus .

mSystems. 2024-10-22

[3]
Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites.

J Fungi (Basel). 2024-8-8

[4]
Research Progress on the Mechanism and Function of Histone Acetylation Regulating the Interaction between Pathogenic Fungi and Plant Hosts.

J Fungi (Basel). 2024-7-26

[5]
A key component Rxt3 in the Rpd3L histone deacetylase complex regulates development, stress tolerance, amylase production and kojic acid synthesis in Aspergillus oryzae.

Biotechnol Lett. 2024-12

[6]
Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus.

Commun Biol. 2024-6-8

[7]
Activation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase.

Appl Microbiol Biotechnol. 2024-5-11

[8]
The CRZ1 transcription factor in plant fungi: regulation mechanism and impact on pathogenesis.

Mol Biol Rep. 2024-5-10

[9]
Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi.

Biotechnol Lett. 2024-6

[10]
The jet-like chromatin structure defines active secondary metabolism in fungi.

Nucleic Acids Res. 2024-5-22

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索