O'Connell M J, Gunderson L L, Fleming T R
Division of Medical and Radiation Oncology, Mayo Clinic, Rochester, MN 55905.
Semin Oncol. 1988 Apr;15(2):138-45.
Surgery is the preferred method of curative therapy for carcinoma of the rectum. However, in spite of complete gross tumor resection, many patients with locally advanced tumors will experience recurrence of malignant disease in the pelvis and/or distant metastases. This article summarizes the roles of radiotherapy and chemotherapy, administered alone and in combination, as surgical adjuvant treatment for patients with resectable rectal cancer. A biostatistical overview is presented. It is concluded that strong evidence exists supporting the efficacy of combined postoperative radiotherapy and chemotherapy. Further clinical trials are indicated to determine the optimum chemotherapy regimen, sequence, and duration of the therapy.
手术是直肠癌根治性治疗的首选方法。然而，尽管肿瘤在肉眼下被完全切除，但许多局部晚期肿瘤患者仍会出现盆腔恶性疾病复发和/或远处转移。本文总结了单独及联合应用放疗和化疗作为可切除直肠癌患者手术辅助治疗的作用。给出了生物统计学概述。得出的结论是，有强有力的证据支持术后放疗和化疗联合应用的疗效。需要进一步开展临床试验以确定最佳化疗方案、治疗顺序和疗程。
