Deeg H J
Vincent T. Lombardi Cancer Research Center, Georgetown University, Washington, D.C.
Transplantation. 1988 May;45(5):845-51. doi: 10.1097/00007890-198805000-00001.
Ultraviolet irradiation, particularly in the UVB range, has profound effects on immunological mechanisms. Optimum and tolerable doses of exposure vary from species to species, and from organ to organ. As a result of limited depth penetration and possibly significant energy absorption in nontargeted cells, every model requires diligent determination of an effective nontoxic approach. Nevertheless, it is clear that UVB and UVC irradiation can abolish proliferative and stimulatory ability as well as accessory/antigen-presenting ability of leukocytes in vitro. UV treatment alters cell-surface properties, calcium mobilization, cytokine production and release, and other subcellular processes. Preliminary data suggest that these manipulations also suppress immunity and reduce immunogenicity in vivo. Exposure of solid organs and of large volumes of blood is difficult due to technical problems--in particular poor depth penetration and absorption of UV energy in generally available transfusion bags.
紫外线照射，尤其是中波紫外线（UVB）范围内的照射，对免疫机制有深远影响。最佳和可耐受的暴露剂量因物种和器官而异。由于紫外线穿透深度有限，且在非靶细胞中可能存在大量能量吸收，因此每个模型都需要认真确定一种有效的无毒方法。然而，很明显，UVB和UVC照射在体外可消除白细胞的增殖和刺激能力以及辅助/抗原呈递能力。紫外线处理会改变细胞表面特性、钙动员、细胞因子的产生和释放以及其他亚细胞过程。初步数据表明，这些操作在体内也会抑制免疫并降低免疫原性。由于技术问题，尤其是紫外线能量在一般可用的输血袋中穿透深度差和吸收不良，对实体器官和大量血液进行照射很困难。
