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颌骨平滑肌肉瘤：病例系列

Leiomyosarcoma of the jaw: case series.

作者信息

Choi Yong-Suk, Almansoori Akram Abdo, Jung Tae-Young, Lee Jae-Il, Kim Soung Min, Lee Jong-Ho

机构信息

Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, Seoul, Korea.

Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital, Seoul, Korea.

出版信息

J Korean Assoc Oral Maxillofac Surg. 2020 Aug 31;46(4):275-281. doi: 10.5125/jkaoms.2020.46.4.275.

DOI:10.5125/jkaoms.2020.46.4.275
PMID:32855375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469964/
Abstract

OBJECTIVES

Leiomyosarcoma is a malignant neoplasm that affects smooth muscle tissue and it is very rare in the field of oral and maxillofcial surgery. The purpose of this study was to obtain information on diagnosis of and treatment methods for leiomyosarcoma by retrospectively reviewing of the cases.

PATIENTS AND METHODS

The study included nine patients who were diagnosed with leiomyosarcoma in the Department of Oral and Maxillofacial Surgery at Seoul National University Dental Hospital. The subjects were analyzed with respect to sex, age, clinical features, primary site of disease, treatment method, recurrence, and metastasis.

RESULTS

Particular clinical features included pain, edema, mouth-opening limitations, dysesthesia, and enlarged lymph nodes. All cases except one were surgically treated, and recurrence was found in two cases. Four of nine patients were followed up without recurrence and one patient underwent additional surgery due to recurrence.

CONCLUSION

In our case series, notable symptoms included pain, edema, mouth-opening limitations, and dysesthesia; however, it was difficult to label these as specific symptoms of leiomyosarcoma. Considering the aggressive characteristics of the disease and poor prognosis, surgical treatment is necessary with careful consideration of postoperative radiotherapy and chemotherapy.

摘要

目的

平滑肌肉瘤是一种影响平滑肌组织的恶性肿瘤，在口腔颌面外科领域非常罕见。本研究的目的是通过回顾病例来获取有关平滑肌肉瘤诊断和治疗方法的信息。

患者与方法

本研究纳入了9例在首尔国立大学牙科学院口腔颌面外科被诊断为平滑肌肉瘤的患者。对这些受试者的性别、年龄、临床特征、疾病原发部位、治疗方法、复发和转移情况进行了分析。

结果

特定的临床特征包括疼痛、水肿、张口受限、感觉异常和淋巴结肿大。除1例患者外，所有病例均接受了手术治疗，2例患者出现复发。9例患者中有4例接受随访且无复发，1例患者因复发接受了再次手术。

结论

在我们的病例系列中，显著症状包括疼痛、水肿、张口受限和感觉异常；然而，很难将这些症状标记为平滑肌肉瘤的特异性症状。考虑到该疾病的侵袭性特征和不良预后，手术治疗是必要的，同时要仔细考虑术后放疗和化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/7c81c98da928/JKAOMS-46-275-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/9b64d49caae4/JKAOMS-46-275-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/431a700e6dd7/JKAOMS-46-275-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/7c81c98da928/JKAOMS-46-275-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/9b64d49caae4/JKAOMS-46-275-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/431a700e6dd7/JKAOMS-46-275-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4746/7469964/7c81c98da928/JKAOMS-46-275-f3.jpg

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Oral leiomyosarcoma: the importance of early diagnosis.口腔平滑肌肉瘤：早期诊断的重要性。
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Head and neck leiomyosarcoma.头颈部平滑肌肉瘤
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