Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
J Oral Pathol Med. 2019 Oct;48(9):780-787. doi: 10.1111/jop.12858. Epub 2019 Apr 25.
The aim of this systematic review was to address the clinicopathologic inconsistencies noted with primary oral leiomyosarcoma in the literature by amassing the available data published into a comprehensive analysis. Eligibility criteria included publications of cases with dedicated immunohistochemical work-up along with radiographs to evaluate location. Based on these criteria, the systematic review compiled 29 cases. Four primary location sites were identified in the reported cases: soft tissue presentation only, soft tissue with bony involvement, bony involvement only, and bony involvement with a soft tissue component. The majority of primary oral leiomyosarcoma cases reviewed showed a soft tissue predilection, which is in contrast to prior reports of jawbones being the most common site. In addition, there was an improved 5-year survival rate for primary oral leiomyosarcoma limited to the oral cavity and gnathic bones without extension into paranasal sinuses.
本系统评价的目的是通过汇集已发表的可用数据进行综合分析，解决文献中原发性口腔平滑肌肉瘤的临床病理不一致性。纳入标准包括具有专门免疫组织化学检查和评估位置的放射学检查的病例报告。基于这些标准，系统评价共纳入了 29 例病例。在报告的病例中确定了四个主要部位：仅软组织表现、软组织伴骨累及、仅骨累及和骨累及伴软组织成分。回顾的大多数原发性口腔平滑肌肉瘤病例表现出软组织倾向，这与先前报道的颌骨是最常见部位的观点相反。此外，原发性口腔平滑肌肉瘤仅限于口腔和颌骨且不向鼻窦扩展的患者，5 年生存率有所提高。
