Nappi Rossella E, Palacios Santiago, Bruyniks Nico, Particco Martire, Panay Nick
Research Centre for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy.
Palacios Institute of Women's Health, Madrid, Spain.
Gynecol Endocrinol. 2021 Jan;37(1):78-82. doi: 10.1080/09513590.2020.1813273. Epub 2020 Aug 28.
Women with history of breast cancer (HBC) frequently suffer from vulvovaginal atrophy (VVA). European Vulvovaginal Epidemiology Survey (EVES) sub-analysis assesses the impact of HBC on VVA, sexual life and quality of life (QoL) in postmenopausal women.
Women with at least one VVA symptom aged 45-75 years were included. EuroQol (EQ-5D-3L) and Day-to-Day Impact of Vaginal Aging (DIVA) questionnaires were filled to investigate QoL. VVA diagnosis was confirmed with objective gynecological examination. Comparison of postmenopausal women with and without HBC, and evaluation of treatment impact on VVA were performed.
1985 postmenopausal women without HBC and 175 with HBC were included. VVA was confirmed in 90.4% of women without HBC and 91.4% of women with HBC. There were no differences in VVA symptoms severity or vulvovaginal discomfort between groups. However, women with HBC who had completed treatment and had surgery 11-20 years previously versus those without HBC presented significantly worse Vaginal Health Index scores, as well as a higher prevalence of VVA objective diagnosis, although their overall symptom severity score was lower. Health status and QoL comparisons were similar.
Results support a similar burden in terms of VVA prevalence and symptoms, QoL and sexual function in postmenopausal women with and without HBC.
有乳腺癌病史（HBC）的女性常患有外阴阴道萎缩（VVA）。欧洲外阴阴道流行病学调查（EVES）子分析评估了HBC对绝经后女性VVA、性生活及生活质量（QoL）的影响。
纳入年龄在45 - 75岁、至少有一项VVA症状的女性。填写欧洲生活质量量表（EQ - 5D - 3L）和阴道老化日常影响（DIVA）问卷以调查生活质量。通过客观的妇科检查确诊VVA。对有和没有HBC的绝经后女性进行比较，并评估治疗对VVA的影响。
纳入了1985名无HBC的绝经后女性和175名有HBC的绝经后女性。无HBC的女性中90.4%确诊为VVA，有HBC的女性中91.4%确诊为VVA。两组之间VVA症状严重程度或外阴阴道不适无差异。然而，与无HBC的女性相比，11 - 20年前完成治疗并接受手术的有HBC的女性，其阴道健康指数得分明显更差，VVA客观诊断的患病率更高，尽管其总体症状严重程度得分较低。健康状况和生活质量比较相似。
结果支持，在VVA患病率、症状、生活质量和性功能方面，有和没有HBC的绝经后女性负担相似。
