Mangiavacchi Francesca, Coelho Dias Italo Franco, Di Lorenzo Irene, Grzes Pawel, Palomba Martina, Rosati Ornelio, Bagnoli Luana, Marini Francesca, Santi Claudio, Lenardao Eder Joao, Sancineto Luca
Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06100 Perugia (PG), Italy.
Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas 96010-900, Brazil.
Pharmaceuticals (Basel). 2020 Aug 26;13(9):211. doi: 10.3390/ph13090211.
In the last decades, organoselenium compounds gained interest due to their important biological features. However, the lack of solubility, which characterizes most of them, makes their actual clinical exploitability a hard to reach goal. Selenosugars, with their intrinsic polarity, do not suffer from this issue and as a result, they can be conceived as a useful alternative. The aim of this review is to provide basic knowledge of the synthetic aspects of selenosugars, selenonium salts, selenoglycosides, and selenonucleotides. Their biological properties will be briefly detailed. Of course, it will not be a comprehensive dissertation but an analysis of what the authors think is the cream of the crop of this interesting research topic.
在过去几十年中，有机硒化合物因其重要的生物学特性而受到关注。然而，它们大多具有缺乏溶解性的特点，这使得其实际临床应用成为一个难以实现的目标。硒糖具有内在的极性，不存在这个问题，因此可以被视为一种有用的替代品。本综述的目的是提供有关硒糖、硒鎓盐、硒糖苷和硒核苷酸合成方面的基础知识。将简要详细介绍它们的生物学特性。当然，这不会是一篇全面的论文，而是作者对这个有趣研究主题中精华部分的分析。
