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转移性肺腺癌中 ncRNA 相关 ceRNA 网络的表征。

Characterization of a non-coding RNA-associated ceRNA network in metastatic lung adenocarcinoma.

机构信息

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

J Cell Mol Med. 2020 Oct;24(20):11680-11690. doi: 10.1111/jcmm.15778. Epub 2020 Aug 29.

DOI:10.1111/jcmm.15778
PMID:32860342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7579711/
Abstract

Lung adenocarcinoma (LUAD) is a highly malignant cancer. Although competing endogenous RNA (ceRNA)-based profiling has been investigated in patients with LUAD, it has not been specifically used to study metastasis in LUAD. We found 130 differentially expressed (DE) lncRNAs, 32 DE miRNAs and 981 DE mRNAs from patients with LUAD in The Cancer Genome Atlas (TCGA) database. We analysed the functions and pathways of 981 DE mRNAs using the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Based on the target DE mRNAs and DE lncRNAs of DE miRNAs, we established an lncRNA-miRNA-mRNA ceRNA network, comprising 37 DE lncRNAs, 22 DE miRNAs and 212 DE mRNAs. Subsequently, we constructed a protein-protein interaction network of DE mRNAs in the ceRNA network. Among all, DE RNAs, 5 DE lncRNAs, 5 DE miRNAs and 45 DE mRNAs were confirmed found to be associated with clinical prognosis. Moreover, 3 DE lncRNAs, 4 DE miRNAs and 9 DE mRNAs in the ceRNA network were associated with clinical prognosis. We further screened 3 DE lncRNAs, 3 DE miRNAs and 3 DE mRNAs using clinical samples. These DE lncRNAs, DE miRNAs and DE mRNAs in ceRNA network may serve as independent biomarkers of LUAD metastasis.

摘要

肺腺癌（LUAD）是一种高度恶性的癌症。尽管在 LUAD 患者中已经研究了竞争内源性 RNA（ceRNA）的分析，但尚未专门用于研究 LUAD 的转移。我们从癌症基因组图谱（TCGA）数据库中发现了 130 个差异表达（DE）lncRNA、32 个 DE miRNA 和 981 个 DE mRNA。我们使用基因本体论（GO）和京都基因与基因组百科全书（KEGG）数据库分析了 981 个 DE mRNA 的功能和途径。基于 DE miRNA 的靶 DE mRNAs 和 DE lncRNAs，我们建立了一个 lncRNA-miRNA-mRNA ceRNA 网络，包含 37 个 DE lncRNA、22 个 DE miRNA 和 212 个 DE mRNA。随后，我们构建了 ceRNA 网络中 DE mRNAs 的蛋白质-蛋白质相互作用网络。在所有这些 DE RNA 中，有 5 个 DE lncRNA、5 个 DE miRNA 和 45 个 DE mRNA 被证实与临床预后相关。此外，ceRNA 网络中的 3 个 DE lncRNA、4 个 DE miRNA 和 9 个 DE mRNA 与临床预后相关。我们进一步使用临床样本筛选了 3 个 DE lncRNA、3 个 DE miRNA 和 3 个 DE mRNA。ceRNA 网络中的这些 DE lncRNA、DE miRNA 和 DE mRNA 可能是 LUAD 转移的独立生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/fa6932b2b3df/JCMM-24-11680-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/0fb1dbd80e96/JCMM-24-11680-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/a40a65d6071c/JCMM-24-11680-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/549a4dd39ca8/JCMM-24-11680-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/40cc054c4e92/JCMM-24-11680-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/e50ec8943f55/JCMM-24-11680-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/982fec666b5e/JCMM-24-11680-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/fa6932b2b3df/JCMM-24-11680-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/0fb1dbd80e96/JCMM-24-11680-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/a40a65d6071c/JCMM-24-11680-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/549a4dd39ca8/JCMM-24-11680-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/40cc054c4e92/JCMM-24-11680-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/e50ec8943f55/JCMM-24-11680-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/982fec666b5e/JCMM-24-11680-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b1d/7579711/fa6932b2b3df/JCMM-24-11680-g007.jpg

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本文引用的文献

1
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Eur J Pharmacol. 2019 Sep 15;859:172465. doi: 10.1016/j.ejphar.2019.172465. Epub 2019 Jun 15.
2
Survival analysis and functional annotation of long non-coding RNAs in lung adenocarcinoma.肺腺癌中长非编码 RNA 的生存分析和功能注释。
J Cell Mol Med. 2019 Aug;23(8):5600-5617. doi: 10.1111/jcmm.14458. Epub 2019 Jun 18.
3
HCP5 is a SMAD3-responsive long non-coding RNA that promotes lung adenocarcinoma metastasis via miR-203/SNAI axis.
用于预测胃癌预后的免疫相关九微小RNA特征
Front Genet. 2021 Jul 5;12:690598. doi: 10.3389/fgene.2021.690598. eCollection 2021.
4
ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma.醛脱氢酶3家族成员A1（ALDH3A1）驱动肿瘤转移是由p53/BAG1在肺腺癌中介导的。
J Cancer. 2021 Jun 11;12(16):4780-4790. doi: 10.7150/jca.58250. eCollection 2021.
5
A Seven-Long Non-coding RNA Signature Improves Prognosis Prediction of Lung Adenocarcinoma: An Integrated Competing Endogenous RNA Network Analysis.一种七长非编码RNA特征改善肺腺癌预后预测：综合竞争性内源性RNA网络分析
Front Genet. 2021 Jan 28;11:625977. doi: 10.3389/fgene.2020.625977. eCollection 2020.
HCP5 是一个 SMAD3 反应性的长非编码 RNA，通过 miR-203/SNAI 轴促进肺腺癌转移。
Theranostics. 2019 Apr 13;9(9):2460-2474. doi: 10.7150/thno.31097. eCollection 2019.
4
Identification of a putative competitive endogenous RNA network for lung adenocarcinoma using TCGA datasets.利用TCGA数据集鉴定肺腺癌潜在的竞争性内源性RNA网络。
PeerJ. 2019 Apr 23;7:e6809. doi: 10.7717/peerj.6809. eCollection 2019.
5
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6
Overexpression of LncRNA-UCA1 Correlates with Lung Adenocarcinoma Progression and Poor Prognosis.长链非编码RNA-UCA1的过表达与肺腺癌进展及不良预后相关。
Clin Lab. 2019 Mar 1;65(3). doi: 10.7754/Clin.Lab.2018.180739.
7
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Cell Death Dis. 2019 Jan 28;10(2):84. doi: 10.1038/s41419-019-1361-3.
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