Centre for Infertility, Prenatal Medicine, Endocrinology and Osteology, amedes Hamburg, Hamburg, Germany.
Fertility Centre KITZ Regensburg, Regensburg, Germany.
Acta Obstet Gynecol Scand. 2020 Dec;99(12):1579-1583. doi: 10.1111/aogs.13984. Epub 2020 Sep 14.
Fertility preservation in women with Turner syndrome is highly controversial. Some strongly recommend freezing of ovarian tissue at a young age, others do not. The controversy is partly due to different perspectives and professions. Biologists prefer to freeze young ovaries with high follicle density, reproductive physicians want to avoid risky operations and iatrogenic infertility by removing one ovary, and cardiologists and obstetricians warn against the risks of later pregnancies. Accordingly, fertility preservation in young women with Turner syndrome is more than just the freezing of ovarian tissue or oocytes. Fertility preservation requires a balanced decision considering the conservation of fertility, the protection of reproductive health, and future health consequences. Therefore, fertility preservation strategies should be based not only on the individual ovarian reserve but also on the genotype and the expected cardiac health status to decide what is the best option: to freeze tissue or alternatively to wait and see.
特纳综合征女性的生育力保存存在很大争议。一些人强烈建议在年轻时冷冻卵巢组织，而另一些人则不建议。这种争议部分归因于不同的观点和专业领域。生物学家倾向于冷冻卵泡密度高的年轻卵巢，生殖医生则希望通过切除一侧卵巢来避免有风险的手术和医源性不孕，而心脏病专家和妇产科医生则警告说要注意以后怀孕的风险。因此，特纳综合征年轻女性的生育力保存不仅仅是卵巢组织或卵子的冷冻。生育力保存需要在考虑到保留生育能力、保护生殖健康和未来健康后果的情况下做出平衡的决策。因此，生育力保存策略不仅应基于个体的卵巢储备情况，还应基于基因型和预期的心脏健康状况来决定哪种方法最佳：是冷冻组织还是等待观察。
