Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China; Medical School of Ningbo University, Ningbo 315211, China.
Medical School of Ningbo University, Ningbo 315211, China.
Biomed Pharmacother. 2020 Nov;131:110680. doi: 10.1016/j.biopha.2020.110680. Epub 2020 Aug 28.
Chitinase 3-like protein 1(CHI3L1) participates in physiological and pathophysiological process, such as cell survival, cell proliferation, tissue remodeling, angiogenesis, etc. Some studies demonstrated that CHI3L1 is liver-enriched and has better application value in staging liver fibrosis than platelet ratio index(APRI) and fibrosis-4 index(FIB-4) and that CHI3L1 can be used in monitoring the prognosis of hepatocellular carcinoma (HCC). In this review, we summarized the pathophysiological role and the diagnostic value of CHI3L1 in liver fibrosis in different background and HCC.
几丁质酶 3 样蛋白 1（CHI3L1）参与细胞存活、细胞增殖、组织重塑、血管生成等生理和病理生理过程。一些研究表明，CHI3L1 是肝脏丰富的，在分期肝纤维化方面比血小板比值指数（APRI）和纤维化 4 指数（FIB-4）具有更好的应用价值，并且 CHI3L1 可用于监测肝细胞癌（HCC）的预后。在这篇综述中，我们总结了 CHI3L1 在不同背景下肝纤维化和 HCC 中的病理生理作用和诊断价值。
