Viinikka L, Kääpä P, Ylikorkala O
Children's Hospitals, Universities Helsinki, Finland.
Dev Pharmacol Ther. 1988;11(2):88-91. doi: 10.1159/000457671.
To study the effect of smoking during pregnancy on the production of vasodilatory, antiaggregatory prostacyclin (PGI2) of the neonates, we measured the urinary excretion of 6-keto-prostaglandin F1a (6-keto-PGF1a, a metabolite of PGI2) on the first and on the third or fourth day of life of a group of babies of smoking (BSM, n = 14) and nonsmoking (BNSM, n = 13) mothers. The urinary excretion of 6-keto-PGF1a was similar in both groups (249.8 +/- 18.5, mean +/- SEM, and 262.7 +/- 35.0 pg 6-keto-PGF1a/mmol of creatinine for BSM and BNSM, respectively, on the first day of life; 109.4 +/- 18.6 and 133.3 +/- 18.5 pg/mmol for BSM and BNSM, respectively, on the third or fourth day of life). Thus smoking during pregnancy is not followed by such changes of PGI2 production that they were reflected by changes of urinary 6-keto-PGF1a of newborns on the first or on the third or fourth day of life.
为研究孕期吸烟对新生儿血管舒张性、抗聚集性前列腺素I2（PGI2）生成的影响，我们测定了一组母亲吸烟（BSM，n = 14）和不吸烟（BNSM，n = 13）的婴儿出生第一天及第三天或第四天尿中6 - 酮 - 前列腺素F1α（6 - keto - PGF1α，PGI2的一种代谢产物）的排泄量。两组婴儿出生第一天尿中6 - keto - PGF1α的排泄量相似（BSM组为249.8±18.5，均值±标准误，BNSM组为262.7±35.0 pg 6 - keto - PGF1α/mmol肌酐；出生第三天或第四天，BSM组为109.4±18.6，BNSM组为133.3±18.5 pg/mmol）。因此，孕期吸烟并未导致PGI2生成出现变化，以至于新生儿出生第一天或第三天或第四天尿中6 - keto - PGF1α的变化无法反映这种变化。
