Ylikorkala O, Paatero H, Suhonen L, Viinikka L
Br J Obstet Gynaecol. 1986 Sep;93(9):950-4. doi: 10.1111/j.1471-0528.1986.tb08014.x.
To study the role of the antiaggregatory and vasodilatory prostacyclin (PGI2) during human delivery, serial urine samples collected from 13 women delivered vaginally and from eight delivered abdominally were assayed for 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha, a breakdown product of PGI2) by high-performance-liquid-chromatography and radioimmunoassay. In women delivered vaginally the mean urinary 6-keto-PGF1 alpha concentration was 41.9 (SE 8.3) ng/mmol creatinine, before the onset of labour and increased progressively to a maximum of 186.5 (SE 47.6) ng/mmol creatinine 2 h after delivery irrespective of the use of oxytocin and epidural analgesia. In women delivered by caesarean section under epidural anaesthesia, the urinary 6-keto-PGF1 alpha rose from 33.4 (SE 4.2) ng/mmol creatinine to 2153 (SE 314) ng/mmol creatinine 2 h after section. In both groups the increased levels had fallen by 24 h postpartum to levels below those found before delivery. In neonatal urine 6-keto-PGF1 alpha concentrations were some 12-30 times higher than those in postpartum urine. Thus, vaginal and abdominal delivery is accompanied by significant increases in maternal PGI2 release, perhaps in the myometrium and/or intrauterine tissues. This may be of significance in the regulation of fetoplacental blood flow and in the prevention of intra- and postpartum thrombosis.
为研究抗聚集和血管舒张性前列腺素I2（PGI2）在人类分娩过程中的作用，采用高效液相色谱法和放射免疫分析法，对13例经阴道分娩和8例剖宫产分娩的妇女采集的系列尿液样本进行了6-酮-前列腺素F1α（6-酮-PGF1α，PGI2的分解产物）检测。经阴道分娩的妇女，在临产前尿中6-酮-PGF1α平均浓度为41.9（标准误8.3）ng/mmol肌酐，分娩后2小时逐渐升高至最高值186.5（标准误47.6）ng/mmol肌酐，无论是否使用催产素和硬膜外镇痛。在硬膜外麻醉下行剖宫产的妇女，术后2小时尿中6-酮-PGF1α从33.4（标准误4.2）ng/mmol肌酐升至2153（标准误314）ng/mmol肌酐。两组中升高的水平在产后24小时均降至分娩前水平以下。新生儿尿中6-酮-PGF1α浓度比产后尿中约高12 - 30倍。因此，阴道分娩和剖宫产均伴有母体PGI2释放显著增加，可能发生在子宫肌层和/或子宫内组织。这可能对调节胎儿胎盘血流及预防产时和产后血栓形成具有重要意义。
