Nikiforova I F
Eksp Onkol. 1988;10(1):17-20.
The restriction analysis of breast cancer DNA revealed amplification of c-myc and c-Ha-ras oncogenes in 3 of 19 and 4 of 22 carcinomas, respectively. In two tumours containing amplified c-Ha-ras1-fragment an additional ras-band absent in unchanged lymphatic nodule and blood leukocytes of the same patients was revealed. Amplification of myc gene was registered in poorly differentiated carcinomas with high metastatic potential. c-Ha-ras1 activation (amplification and elevated expression) was identified in nonaggressive tumours with prolonged progression.
乳腺癌DNA的限制性分析显示，在19例癌中有3例c-myc癌基因扩增，在22例癌中有4例c-Ha-ras癌基因扩增。在两个含有扩增的c-Ha-ras1片段的肿瘤中，发现了同一患者未改变的淋巴结和血白细胞中不存在的另一条ras带。myc基因扩增见于具有高转移潜能的低分化癌。c-Ha-ras1激活（扩增和表达升高）见于进展期延长的非侵袭性肿瘤。
